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Cat. No.: HY-173329

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KRAS-IN-41

KRAS-IN-41 is an inhibitor of KRAS with IC₅₀ values of <0.01 μM for KRAS G12D and KRAS G12V. KRAS-IN-41 inhibits RAS mutant cell lines, GP2D (KRAS-G12D) and SW620 (KRAS-G12V). KRAS-IN-41 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 3056974-50-3
Formula: C₃₀H₃₇FN₁₀OS
Molecular Weight:604.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

KRAS-IN-41 Chemical Structure

CAS No.: 3056974-50-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Ras Isoforms :

In Vitro

KRAS-IN-41 (example 173) inhibits the activity of GP2D and SW620 cell lines (IC₅₀s both <0.01 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3056974-50-3
Molecular Weight 604.74
Formula C₃₀H₃₇FN₁₀OS
SMILES

NC1=C([C@@H](C)N(C2=NC(N3CC4(CCC5=C4C(C#N)=C(N)S5)C3)=NC(OC[C@@]6(CCC7)N7C[C@H](F)C6)=N2)CC)C=CC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lin H, et al. Preparation of substituted triazines as Kras modulators and uses thereof. US, WO/2024/192424, 2024-09-19.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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KRAS-IN-41

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KRAS-IN-41 Related Classifications

HY-173329 Related Classifications