2. Cell Cycle/DNA Damage MAPK/ERK Pathway GPCR/G Protein
  3. PERK Ras
  4. KRAS-IN-54

KRAS-IN-54 is a macrocyclic KRAS inhibitor. KRAS-IN-54 exhibits activity against cell viability and pERK inhibition in cells with KRASG12D and KRASG13D mutations. KRAS-IN-54 can be used in the research of KRAS-mutant cancers, including pancreatic adenocarcinoma, colorectal cancer, non-small cell lung cancer, esophageal cancer, gallbladder cancer, melanoma, ovarian cancer and endometrial cancer.

For research use only. We do not sell to patients.

KRAS-IN-54

KRAS-IN-54 Chemical Structure

CAS No. : 3084918-70-4

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KRAS-IN-54 Related Antibodies

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Description

KRAS-IN-54 is a macrocyclic KRAS inhibitor. KRAS-IN-54 exhibits activity against cell viability and pERK inhibition in cells with KRASG12D and KRASG13D mutations. KRAS-IN-54 can be used in the research of KRAS-mutant cancers, including pancreatic adenocarcinoma, colorectal cancer, non-small cell lung cancer, esophageal cancer, gallbladder cancer, melanoma, ovarian cancer and endometrial cancer[1].

IC50 & Target[1]

KRas G12D

 

KRAS G13D

 

In Vitro

KRAS-IN-54 (compound 3) inhibits the viability of AGS (KRASG12D) cells with an IC50 of 10 nM; it also inhibits the viability of HCT-116 (KRASG13D) cells with an IC50 of 27 nM[1].
KRAS-IN-54 inhibits ERK phosphorylation in AGS (KRASG12D) cells with an IC50 of 9 nM; it also inhibits ERK phosphorylation in HCT-116 (KRASG13D) cells with an IC50 of 10 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS-IN-54 Related Antibodies
Molecular Weight

1192.39

Formula

C60H78F5N11O7S
CAS No.
SMILES

CO[C@H](C1=[C@@](C=C(C=N1)N2CCN(CC2)C)[C@@]3=C4CC(C)(COC([C@@H]5CCCN(C([C@H](CC6=NC(C7=CC4=C(N3CC(F)(F)F)C=C7F)=CS6)NC([C@@H](N(C(C8(F)CCN(C([C@H]9N(C)[C@@H]9C%10CC%10)=O)CC8)=O)C)C%11CCCC%11)=O)=O)N5)=O)C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KRAS-IN-54 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS-IN-543084918-70-4PERKRasProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseKRAS G13Dpancreatic adenocarcinomaovarian cancerKRAS G12Dcolorectal cancerendometrial cancergallbladder canceresophageal cancernon-small cell lung cancermelanomaInhibitorinhibitorinhibit

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