KRAS-IN-54
KRAS-IN-54 is a macrocyclic KRAS inhibitor. KRAS-IN-54 exhibits activity against cell viability and pERK inhibition in cells with KRASG12D and KRASG13D mutations. KRAS-IN-54 can be used in the research of KRAS-mutant cancers, including pancreatic adenocarcinoma, colorectal cancer, non-small cell lung cancer, esophageal cancer, gallbladder cancer, melanoma, ovarian cancer and endometrial cancer.
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- No. CAS: 3084918-70-4
- Fòrmula: C60H78F5N11O7S
- Peso molecular:1192.39
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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KRas G12D |
KRAS G13D |
KRAS-IN-54 (compound 3) inhibits the viability of AGS (KRASG12D) cells with an IC50 of 10 nM; it also inhibits the viability of HCT-116 (KRASG13D) cells with an IC50 of 27 nM[1].
KRAS-IN-54 inhibits ERK phosphorylation in AGS (KRASG12D) cells with an IC50 of 9 nM; it also inhibits ERK phosphorylation in HCT-116 (KRASG13D) cells with an IC50 of 10 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3084918-70-4
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Peso molecular 1192.39
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Fòrmula C60H78F5N11O7S
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SMILES
CO[C@H](C1=[C@@](C=C(C=N1)N2CCN(CC2)C)[C@@]3=C4CC(C)(COC([C@@H]5CCCN(C([C@H](CC6=NC(C7=CC4=C(N3CC(F)(F)F)C=C7F)=CS6)NC([C@@H](N(C(C8(F)CCN(C([C@H]9N(C)[C@@H]9C%10CC%10)=O)CC8)=O)C)C%11CCCC%11)=O)=O)N5)=O)C)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS-IN-54 Related Classifications
HY-181704 Related Classifications
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