Deltarasin trihydrochloride
Based on 2 publication(s) in Google Scholar
Deltarasin is an inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ. Deltarasin can be used in the study of cancer.
For research use only. We do not sell to patients.
- CAS No.: 1440898-82-7
- Formula: C40H40Cl3N5O
- Molecular Weight:713.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Deltarasin trihydrochloride
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
6.4 μM
Compound: Deltarasin
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Antiproliferative activity against human A549 cells harboring KRAS G12S point mutant after 72 hrs by SRB assay
Antiproliferative activity against human A549 cells harboring KRAS G12S point mutant after 72 hrs by SRB assay
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[PMID: 30562696] |
Chemical Information
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CAS No. 1440898-82-7
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Molecular Weight 713.14
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Formula C40H40Cl3N5O
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SMILES
C1(CN2C3=CC=CC=C3N=C2C4=CC=C(OC[C@@H](N5C6=CC=CC=C6N=C5C7=CC=CC=C7)C8CCNCC8)C=C4)=CC=CC=C1.Cl.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
[1]. Zimmermann G, et al. Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature. 2013 May 30;497(7451):638-42. [Content Brief]
[2]. Agalioti T, et al. Mutant KRAS promotes malignant pleural effusion formation. Nat Commun. 2017 May 16;8:15205. doi: 10.1038/ncomms15205. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Deltarasin trihydrochloride Related Classifications
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