VVD-484
VVD-484 is a PI3K p110α inhibitor with an IC50 of 0.59 μM against human targets.,VVD-484, classified as a "silent ligand", forms a covalent bond with Cys242 of PI3K p110α without disrupting the p110α-KRASG12C interaction. VVD-484 inhibits phosphorylation (S473) of AKT via a RAS-independent pathway. VVD-484 can be used in the research of HER2-overexpressing cancers.
For research use only. We do not sell to patients.
- CAS No.: 3055745-21-3
- Formula: C24H29ClF2N2O3
- Molecular Weight:466.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
VVD-484 (2 h) potently inhibits PI3K/AKT signaling in N87 HER2-overexpressing gastric cancer cells, despite not disrupting the RAS-p110α interaction[1].
VVD-484 does not disrupt the interaction between p110α and alternate RAS isoforms (RRAS, ERAS, MRAS, RRAS2) in H358 cell lysates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3055745-21-3
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Molecular Weight 466.95
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Formula C24H29ClF2N2O3
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SMILES
FC1(C2(CCN(C1)C([C@H]3[C@@H](C4=C(C=CC=C4)Cl)CC(C)(OC3)C)=O)CN(C2)C(C=C)=O)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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