3055745-21-3
Chemical Structure
VVD-484
- CAS No.: 3055745-21-3
- Formula:C24H29ClF2N2O3
- Molecular Weight:466.95
InChIKey: YIIMJZMCUAOYKW-QZTJIDSGSA-N
SMILES: FC1(C2(CCN(C1)C([C@H]3[C@@H](C4=C(C=CC=C4)Cl)CC(C)(OC3)C)=O)CN(C2)C(C=C)=O)F
Biological Activity: VVD-484 is a PI3K p110α inhibitor with an IC50 of 0.59 μM against human targets.,VVD-484, classified as a "silent ligand", forms a covalent bond with Cys242 of PI3K p110α without disrupting the p110α-KRASG12C interaction. VVD-484 inhibits phosphorylation (S473) of AKT via a RAS-independent pathway. VVD-484 can be used in the research of HER2-overexpressing cancers[1].
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VVD-484 | VVD-484 is a PI3K p110α inhibitor with an IC50 of 0.59 μM against human targets.,VVD-484, classified as a "silent ligand", forms a covalent bond with Cys242 of PI3K p110α without disrupting the p110α-KRASG12C interaction. VVD-484 inhibits phosphorylation (S473) of AKT via a RAS-independent pathway. VVD-484 can be used in the research of HER2-overexpressing cancers. | |||||||||||||||||||||
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Keywords
