KRAS inhibitor-24
Based on 1 Customer Validation
KRAS inhibitor-24 (compound 115c) is a pyridopyrimidine KRAS inhibitor, with an IC50 of < 100 nM for KRas G12V, KRas WT and KRas G12R.
For research use only. We do not sell to patients.
- Purity : 95.03%
- CAS No.: 3030576-47-4
- Formula: C33H39ClF2N6O3
- Molecular Weight:641.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1].|
KRas G12V < 100 nM (IC50) |
K-Ras WT < 100 nM (IC50) |
KRas G12R < 100 nM (IC50) |
Chemical Information
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CAS No. 3030576-47-4
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Appearance Solid
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Molecular Weight 641.15
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Formula C33H39ClF2N6O3
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Color White to off-white
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SMILES
FC1=C(C2=CC(O)=CC(Cl)=C2CCCCC(NCC[C@@]3([H])CN4CCC3)=O)N=CC(C1=N5)=C4N=C5OC[C@@]67N(CCC7)C[C@@H](C6)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS inhibitor-24 Related Classifications
HY-159474 Related Classifications
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