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Cat. No.: HY-159474A

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(1R)-KRAS inhibitor-24

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(1R)-KRAS inhibitor-24 (compound 115c) is a pyridopyrimidine KRAS inhibitor, with an IC₅₀ of < 100 nM for KRas G12V, KRas WT and KRas G12R.

For research use only. We do not sell to patients.

Purity: 98.29%
CAS No.: 3030576-46-3
Formula: C₃₃H₃₉ClF₂N₆O₃
Molecular Weight:641.16

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

(1R)-KRAS inhibitor-24 Chemical Structure

CAS No.: 3030576-46-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(1R)-KRAS inhibitor-24 (compound 115c) is a pyridopyrimidine KRAS inhibitor, with an IC₅₀ of < 100 nM for KRas G12V, KRas WT and KRas G12R^[1].

IC₅₀ & Target^[1]

KRas G12V

< 100 nM (IC₅₀)

K-Ras WT

< 100 nM (IC₅₀)

KRas G12R

< 100 nM (IC₅₀)

All Ras Isoforms :

Chemical Information

CAS No. 3030576-46-3
Appearance Solid
Molecular Weight 641.16
Formula C₃₃H₃₉ClF₂N₆O₃
Color White to off-white
SMILES

C(OC1=NC2=C3C(=N1)C(F)=C(N=C3)C=4C(=C(Cl)C=C(O)C4)CCCCC(=O)NCC[C@@]5(CN2CCC5)[H])[C@@]67N(C[C@H](F)C6)CCC7
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. James Paul LAJINESS, et al. Pyridopyrimidine kras inhibitors. Patent WO 2024/040131 A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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(1R)-KRAS inhibitor-24

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(1R)-KRAS inhibitor-24 Related Classifications

HY-159474A Related Classifications