K-Ras ligand-Linker Conjugate 6 formate

Cat. No.: HY-130991A Pureza: 98.93%: Ficha de datos
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K-Ras ligand-Linker Conjugate 6 formate incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 formate can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.

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K-Ras ligand-Linker Conjugate 6 formate Estructura química

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
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500 mg	Obtener un presupuesto

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Based on 1 publication(s) in Google Scholar

Other Forms of K-Ras ligand-Linker Conjugate 6 formate:

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Descripciòn	K-Ras ligand-Linker Conjugate 6 formate incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 formate can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells^[1].
Peso molecular	835.00
Fòrmula	C₄₃H₆₂N₈O₉
Appearance	Solid
Color	Off-white to light yellow
SMILES	O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCN)C6)=N2)CC1)OC(C)(C)C.OC=O
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureza y Documentación	Purity: 98.93% Select Batch: Ficha de datos (266 KB) SDS (251 KB) COA (250 KB) HNMR (445 KB) RP-HPLC (261 KB) MS (85 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.