2. PROTAC
  3. Target Protein Ligand-Linker Conjugates
  4. K-Ras ligand-Linker Conjugate 6

K-Ras ligand-Linker Conjugate 6 

Cat. No.: HY-130991 Purity: 95.18%
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K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.

For research use only. We do not sell to patients.

K-Ras ligand-Linker Conjugate 6 Chemical Structure

K-Ras ligand-Linker Conjugate 6 Chemical Structure

CAS No. : 2378261-89-1

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Based on 1 publication(s) in Google Scholar

K-Ras ligand-Linker Conjugate 6 Related Antibodies

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Description

K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

K-Ras ligand-Linker Conjugate 6 Related Antibodies
Molecular Weight

788.98

Formula

C42H60N8O7
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCN)C6)=N2)CC1)OC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
References
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K-Ras ligand-Linker Conjugate 6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K-Ras ligand-Linker Conjugate 62378261-89-1Target Protein Ligand-Linker ConjugatesK-RasE3ligasesVHLCRBNMDM2IAPproteindegradationPROTACDegrader-1Inhibitorinhibitorinhibit

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