PDEδ autophagic degrader 1

Autophagosome-binding compounds (ATTECs) are small molecule compounds that simultaneously bind to both the target protein and the autophagosome membrane surface protein LC3. They directly tether the target protein to the autophagosome membrane via a molecular glue mechanism, allowing for selective degradation of the target protein through the autophagy-lysosome pathway. This differs from PROTACs, which achieve targeted protein clearance without relying on ubiquitination labeling. Subsequently, under lysosome-mediated autophagy, the cell forms a double-membrane structure called autophagosomes, which encapsulate the target protein or damaged organelle to be degraded. These autophagosomes then fuse with lysosomes to form autolysosomes, where degradation and recycling are completed under the action of acidic hydrolases. This cell self-renewal and quality control mechanism is crucial for maintaining cellular homeostasis, clearing abnormal protein aggregates, and resisting nutrient stress.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.