2. Autophagy PROTAC Metabolic Enzyme/Protease
  3. ATTECs Phosphodiesterase (PDE) Autophagy
  4. PDEδ autophagic degrader 1

PDEδ autophagic degrader 1 (compound 12c), an autophagosome-tethering compound (ATTEC). is a potent PDEδ autophagic degrader. PDEδ autophagic degrader 1 reduces the PDEδ protein level through lysosome-mediated autophagy without affecting the PDEδ mRNA expression. PDEδ autophagic degrader 1 suppresses the growth in KRAS mutant pancreatic cancer cells.

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PDEδ autophagic degrader 1

PDEδ autophagic degrader 1 Estructura química

No. CAS : 3054112-59-0

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PDEδ autophagic degrader 1 Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Descripciòn

PDEδ autophagic degrader 1 (compound 12c), an autophagosome-tethering compound (ATTEC). is a potent PDEδ autophagic degrader. PDEδ autophagic degrader 1 reduces the PDEδ protein level through lysosome-mediated autophagy without affecting the PDEδ mRNA expression. PDEδ autophagic degrader 1 suppresses the growth in KRAS mutant pancreatic cancer cells[1].

IC50 & Target

Kd: 56 nM (PDEδ)[1]
Cellular Effect
Cell Line Type Value Description References
CAPAN-1 IC50
0.8 μM
Compound: 12c
Antiproliferative activity against human CAPAN-1 cells harboring KRAS mutant assessed as reduction in cell proliferation incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human CAPAN-1 cells harboring KRAS mutant assessed as reduction in cell proliferation incubated for 72 hrs by CCK-8 assay
[PMID: 38229750]
MIA PaCa-2 IC50
1.4 μM
Compound: 12c
Antiproliferative activity against human MIA PaCa-2 cells harboring KRAS mutant assessed as reduction in cell proliferation incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MIA PaCa-2 cells harboring KRAS mutant assessed as reduction in cell proliferation incubated for 72 hrs by CCK-8 assay
[PMID: 38229750]
Peso molecular

999.53

Fòrmula

C41H42Br2IN7O5
No. CAS
SMILES

O=C(NCCCCCCNC(COC1=C(Br)C=C(/C=C2C(NC3=C\2C=C(I)C=C3)=O)C=C1Br)=O)CCCN4N=C(C)C5=C(C)N(C6=CC=C(C)C=C6)N=C5C4=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Pureza y Documentación
Referencias
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PDEδ autophagic degrader 1 Related Classifications

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Keywords:

PDEδ autophagic degrader 13054112-59-0PDEδ autophagic degrader1PDEδ autophagic degrader-1ATTECsPhosphodiesterase (PDE)AutophagyAutophagosome-tethering compoundsATTECPDEδ autophagicKRAS mutantInhibitorinhibitorinhibit

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Nombre del producto:
PDEδ autophagic degrader 1
Cat. No.:
HY-157458
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