KRAS G12D inhibitor 3 TFA
Based on 1 Customer Validation
KRAS G12D inhibitor 3 TFA is a KRAS G12D inhibitor with an IC50 of <500 nM. KRAS G12D inhibitor 3 TFA has antitumor effects (WO2022002102A1; compound 146). KRAS G12D inhibitor 3 (TFA) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 98.18%
- CAS No.: 2757095-12-6
- Formula: C36H32ClF6N5O4
- Molecular Weight:748.11
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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KRas G12D <500 nM (IC50) |
Chemical Information
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CAS No. 2757095-12-6
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Appearance Solid
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Molecular Weight 748.11
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Formula C36H32ClF6N5O4
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Color Light yellow to yellow
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SMILES
C#CC1=C(C=CC2=C1C(C3=C(C4=C(C(N5CC6CCC(N6)C5)=NC(OC[C@@]78CCCN7C[C@@H](C8)F)=N4)C=C3Cl)F)=CC(O)=C2)F.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (133.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3367 mL | 6.6835 mL | 13.3670 mL | 33.4175 mL |
| 5 mM | 0.2673 mL | 1.3367 mL | 2.6734 mL | 6.6835 mL | |
| 10 mM | 0.1337 mL | 0.6684 mL | 1.3367 mL | 3.3418 mL | |
| 15 mM | 0.0891 mL | 0.4456 mL | 0.8911 mL | 2.2278 mL | |
| 20 mM | 0.0668 mL | 0.3342 mL | 0.6684 mL | 1.6709 mL | |
| 25 mM | 0.0535 mL | 0.2673 mL | 0.5347 mL | 1.3367 mL | |
| 30 mM | 0.0446 mL | 0.2228 mL | 0.4456 mL | 1.1139 mL | |
| 40 mM | 0.0334 mL | 0.1671 mL | 0.3342 mL | 0.8354 mL | |
| 50 mM | 0.0267 mL | 0.1337 mL | 0.2673 mL | 0.6684 mL | |
| 60 mM | 0.0223 mL | 0.1114 mL | 0.2228 mL | 0.5570 mL | |
| 80 mM | 0.0167 mL | 0.0835 mL | 0.1671 mL | 0.4177 mL | |
| 100 mM | 0.0134 mL | 0.0668 mL | 0.1337 mL | 0.3342 mL |
KRAS G12D inhibitor 3 TFA Related Classifications
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