KRASG12D-IN-1
Based on 1 Customer Validation
KRASG12D-IN-1 (compound 22) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.00%
- Formel: C34H28D2F4N6O2
- Molecular Weight:632.65
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
332 nM
Compound: 22
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Antiproliferative activity against human A549 cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
Antiproliferative activity against human A549 cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
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[PMID: 37921024] |
| AGS | IC50 |
0.3 nM
Compound: 22
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Antiproliferative activity against human AGS cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
Antiproliferative activity against human AGS cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
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[PMID: 37921024] |
| ASPC1 | IC50 |
0.6 nM
Compound: 22
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Antiproliferative activity against human ASPC1 cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
Antiproliferative activity against human ASPC1 cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
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[PMID: 37921024] |
| NCI-H1299 | IC50 |
1942 nM
Compound: 22
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Antiproliferative activity against human NCI-H1299 cells harboring KRAS wild type assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
Antiproliferative activity against human NCI-H1299 cells harboring KRAS wild type assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
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[PMID: 37921024] |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Appearance Solid
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Molecular Weight 632.65
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Formel C34H28D2F4N6O2
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Color Off-white to light yellow
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SMILES
FC1=C(C2=CN=C1C3=C4C(C#C)=C(C=CC4=CC(O)=C3)F)N=C(N=C2N5C[C@H](CC6)N[C@H]6C5)OC([2H])(C78CCCN7C/C(C8)=C(F)\F)[2H]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 71.43 mg/mL (112.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5807 mL | 7.9033 mL | 15.8065 mL | 39.5163 mL |
| 5 mM | 0.3161 mL | 1.5807 mL | 3.1613 mL | 7.9033 mL | |
| 10 mM | 0.1581 mL | 0.7903 mL | 1.5807 mL | 3.9516 mL | |
| 15 mM | 0.1054 mL | 0.5269 mL | 1.0538 mL | 2.6344 mL | |
| 20 mM | 0.0790 mL | 0.3952 mL | 0.7903 mL | 1.9758 mL | |
| 25 mM | 0.0632 mL | 0.3161 mL | 0.6323 mL | 1.5807 mL | |
| 30 mM | 0.0527 mL | 0.2634 mL | 0.5269 mL | 1.3172 mL | |
| 40 mM | 0.0395 mL | 0.1976 mL | 0.3952 mL | 0.9879 mL | |
| 50 mM | 0.0316 mL | 0.1581 mL | 0.3161 mL | 0.7903 mL | |
| 60 mM | 0.0263 mL | 0.1317 mL | 0.2634 mL | 0.6586 mL | |
| 80 mM | 0.0198 mL | 0.0988 mL | 0.1976 mL | 0.4940 mL | |
| 100 mM | 0.0158 mL | 0.0790 mL | 0.1581 mL | 0.3952 mL |
KRASG12D-IN-1 Related Classifications
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