2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. CFL-120

CFL-120 is a potent KRasG12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer.

For research use only. We do not sell to patients.

CFL-120 Chemical Structure

CFL-120 Chemical Structure

CAS No. : 18711-15-4

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CFL-120 Related Antibodies

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Description

CFL-120 is a potent KRasG12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer[1].

IC50 & Target[1]

KRAS(G12C)

 

In Vitro

CFL-120 (72 h) shows an antiproliferative effect with IC50s of 11.0, 23.6, 13.7, 16.9, 44.4, 14.8, 38.0, 30.0, 13.1, 9.8, 47.9, 24.4, 42.7 µM for H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, CCD-986Sk cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CFL-120 Related Antibodies
In Vivo

CFL-120 (5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments; i.p.) reduces tumor growth in subcutaneous H1792 (KRasG12C mutant) and LCLC-103H (KRasWT) human lung cancer-bearing mice[1].
Pharmacokinetic Parameters of CFL-120 in NOD-SCID female mice[1].

PK parameters CFL-137
Cmax (ng/mL) 337 ± 123
Tmax (h) 0.25
AUCt (ng/mL*h) 169 ± 56
t1/2 (h) 4.4 ± 0.6
Vd (mL) 12,096 ± 4000
CL(mL/h) 1895 ± 539
NOD-SCID female mice, 15 mg/kg IP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID female mice (KRasWT (LCLC-103H) or KRasG12C (H1792) tumors)[1]
Dosage: 5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments
Administration: I.p.
Result: Reduced tumor growth compared to the control group in KRasG12C mutated model for 35.8%.
Molecular Weight

216.02

Formula

C8H3Cl2NO2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C1=C(C=C(C2=C1NC(C2=O)=O)Cl)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

COA (251 KB) HNMR (121 KB)

Handling Instructions (2659 KB)
References
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CFL-120 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFL-12018711-15-4CFL120CFL 120RasH1792LCLC-103Hanticancerantiproliferativelung cancerInhibitorinhibitorinhibit

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