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Art. -Nr.: HY-159476

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KRAS inhibitor-26

KRAS inhibitor-26 is a KRas protein inhibitor with activity against dysregulated and mutant KRAS^G12C proteins. KRAS inhibitor-26 modulates KRAS-mediated signaling pathways. KRAS inhibitor-26 can be used for the research of cancer.

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CAS. Nr.: 3030576-80-5
Formel: C₃₆H₃₉F₃N₆O₄
Molecular Weight:676.73

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

KRAS inhibitor-26 Chemical Structure

CAS. Nr.: 3030576-80-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

KRas G12V

≤100 nM (IC₅₀)

Alle Ras Isoform-spezifische Produkte anzeigen :

In Vitro

KRAS inhibitor-26 (Compound 194a) potently inhibits KRAS^G12V (with an IC₅₀ of ≤100 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3030576-80-5
Molecular Weight 676.73
Formel C₃₆H₃₉F₃N₆O₄
SMILES

FC1=C2C(C3=NC(OC[C@@]45N(CCC5)C[C@@H](C4)F)=N2)=CN=C1C6=C7C(C=CC(F)=C7CCCC(NCCC8([H])CN3CCOC8)=O)=CC(O)=C6
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. James Paul LAJINESS, et al. Pyridopyrimidine kras inhibitors. Patent. WO 2024/040131 A1. WIPO (PCT). 2023-08-16.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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