KRAS G13D-IN-1
KRAS G13D-IN-1 (Compound 41) is a selective and covalently reversible inhibitor of KRASG13D (IC50: 0.41 nM). The selectivity for KRASG13D is 29-fold against KRAS wild type. KRAS G13D-IN-1 is an inhibitor of the GDP state and targets the SWII binding pocket of KRASG13D. KRAS G13D-IN-1 inhibits KRAS binding to GDP and turns on/off downstream signaling cascades. KRAS G13D-IN-1 can be used in the research of colon cancer.
For research use only. We do not sell to patients.
- Formula: C43H45ClF4N8O2
- Molecular Weight:817.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KRAS G13D 0.41 nM (IC50) |
Chemical Information
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Molecular Weight 817.32
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Formula C43H45ClF4N8O2
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SMILES
NC1=N[C@@]([C@@]2=C(F)C3=C(C(N4[C@@H](C)CN(C(/C=C/C5=CC=CC6=C5C[N@@]7C[C@H]6CC7)=O)CC4)=NC(OC[C@@]89CCCN8CC(C9)=C)=N3)C=C2Cl)=C(C(F)(F)F)C(C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS G13D-IN-1 Related Classifications
HY-161066 Related Classifications
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