2. PROTAC Anti-infection
  3. PROTACs SARS-CoV Virus Protease
  4. PROTAC SARS-CoV-2 3CLPro degrader 2

PROTAC KRAS G12D degrader 2 is a peptidomimetic PROTAC specifically targeting the dimeric SARS-CoV-2 3CLPro protein. PROTAC KRAS G12D degrader 2 inhibits SARS-CoV-2 3CLPro with an IC50 of 21.2 μM. PROTAC KRAS G12D degrader 2 specifically binds to the active site of SARS-CoV-2 3CLPro. PROTAC KRAS G12D degrader 2 reduces protein levels of SARS-CoV-2 3CLPro without affecting cell viability. PROTAC KRAS G12D degrader 2 can be used for the study of viral infections in Coronavirus genera.
(Pink: SARS-CoV-2 3CLPro Target protein ligand; Blue: Cereblon ligand (HY-W087383); Black: linker).

For research use only. We do not sell to patients.

PROTAC SARS-CoV-2 3CLPro degrader 2

PROTAC SARS-CoV-2 3CLPro degrader 2 Chemical Structure

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg Get quote
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

PROTAC SARS-CoV-2 3CLPro degrader 2 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PROTAC KRAS G12D degrader 2 is a peptidomimetic PROTAC specifically targeting the dimeric SARS-CoV-2 3CLPro protein. PROTAC KRAS G12D degrader 2 inhibits SARS-CoV-2 3CLPro with an IC50 of 21.2 μM. PROTAC KRAS G12D degrader 2 specifically binds to the active site of SARS-CoV-2 3CLPro. PROTAC KRAS G12D degrader 2 reduces protein levels of SARS-CoV-2 3CLPro without affecting cell viability. PROTAC KRAS G12D degrader 2 can be used for the study of viral infections in Coronavirus genera[1]. (Pink: SARS-CoV-2 3CLPro Target protein ligand; Blue: Cereblon ligand (HY-W087383); Black: linker).

In Vitro

PROTAC KRAS G12D degrader 2 (PROTAC 1) (20-80 μM; 12-48 h) decreases SARS-CoV-2 3CLPro protein levels in HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC SARS-CoV-2 3CLPro degrader 2 Related Antibodies

Western Blot Analysis[1]

Cell Line: HeLa cells stably expressing hemagglutinin (HA)-epitope C-terminally tagged SARS-CoV-2 3CLPro by lentiviral transduction
Concentration: 20 μM, 40 μM, 80 μM
Incubation Time: 12 h, 24 h, 48 h
Result: Observed a pronounced decrease in SARS-CoV-2 3CLPro levels.
Did not affect the cell viability.
Molecular Weight

884.99

Formula

C46H57FN8O9
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N[C@@H](CC(C)C)C(N[C@H](/C=C/C(N1CCN(CC2CCN(C3=C(F)C=C(C(N(C(CCC(N4)=O)C4=O)C5=O)=O)C5=C3)CC2)CC1)=O)C[C@@H]6CCNC6=O)=O)OCC7=CC=CC=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (113.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1300 mL 5.6498 mL 11.2996 mL
5 mM 0.2260 mL 1.1300 mL 2.2599 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1300 mL 5.6498 mL 11.2996 mL 28.2489 mL
5 mM 0.2260 mL 1.1300 mL 2.2599 mL 5.6498 mL
10 mM 0.1130 mL 0.5650 mL 1.1300 mL 2.8249 mL
15 mM 0.0753 mL 0.3767 mL 0.7533 mL 1.8833 mL
20 mM 0.0565 mL 0.2825 mL 0.5650 mL 1.4124 mL
25 mM 0.0452 mL 0.2260 mL 0.4520 mL 1.1300 mL
30 mM 0.0377 mL 0.1883 mL 0.3767 mL 0.9416 mL
40 mM 0.0282 mL 0.1412 mL 0.2825 mL 0.7062 mL
50 mM 0.0226 mL 0.1130 mL 0.2260 mL 0.5650 mL
60 mM 0.0188 mL 0.0942 mL 0.1883 mL 0.4708 mL
80 mM 0.0141 mL 0.0706 mL 0.1412 mL 0.3531 mL
100 mM 0.0113 mL 0.0565 mL 0.1130 mL 0.2825 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PROTAC SARS-CoV-2 3CLPro degrader 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SARS-CoV-2 3CLPro degrader 2PROTACsSARS-CoVVirus ProteaseSARS coronavirus3CLProSARS-CoV-2 3-chymotrypsin-like proteaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PROTAC SARS-CoV-2 3CLPro degrader 2
Cat. No.:
HY-161177
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.