PROTAC SARS-CoV-2 3CLPro degrader 2
Based on 1 Customer Validation
PROTAC KRAS G12D degrader 2 is a peptidomimetic PROTAC specifically targeting the dimeric SARS-CoV-2 3CLPro protein. PROTAC KRAS G12D degrader 2 inhibits SARS-CoV-2 3CLPro with an IC50 of 21.2 μM. PROTAC KRAS G12D degrader 2 specifically binds to the active site of SARS-CoV-2 3CLPro. PROTAC KRAS G12D degrader 2 reduces protein levels of SARS-CoV-2 3CLPro without affecting cell viability. PROTAC KRAS G12D degrader 2 can be used for the study of viral infections in Coronavirus genera.
(Pink: SARS-CoV-2 3CLPro Target protein ligand; Blue: Cereblon ligand (HY-W087383); Black: linker).
For research use only. We do not sell to patients.
- Purity: 98.59%
- Formula: C46H57FN8O9
- Molecular Weight:884.99
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
PROTAC KRAS G12D degrader 2 (PROTAC 1) (20-80 μM; 12-48 h) decreases SARS-CoV-2 3CLPro protein levels in HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells stably expressing hemagglutinin (HA)-epitope C-terminally tagged SARS-CoV-2 3CLPro by lentiviral transduction
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Concentration:20 μM, 40 μM, 80 μM
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Incubation Time:12 h, 24 h, 48 h
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Result:Observed a pronounced decrease in SARS-CoV-2 3CLPro levels.
Did not affect the cell viability.
Chemical Information
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Appearance Solid
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Molecular Weight 884.99
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Formula C46H57FN8O9
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Color Light yellow to yellow
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SMILES
O=C(N[C@@H](CC(C)C)C(N[C@H](/C=C/C(N1CCN(CC2CCN(C3=C(F)C=C(C(N(C(CCC(N4)=O)C4=O)C5=O)=O)C5=C3)CC2)CC1)=O)C[C@@H]6CCNC6=O)=O)OCC7=CC=CC=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (113.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.1300 mL | 5.6498 mL | 11.2996 mL | 28.2489 mL |
| 5 mM | 0.2260 mL | 1.1300 mL | 2.2599 mL | 5.6498 mL | |
| 10 mM | 0.1130 mL | 0.5650 mL | 1.1300 mL | 2.8249 mL | |
| 15 mM | 0.0753 mL | 0.3767 mL | 0.7533 mL | 1.8833 mL | |
| 20 mM | 0.0565 mL | 0.2825 mL | 0.5650 mL | 1.4124 mL | |
| 25 mM | 0.0452 mL | 0.2260 mL | 0.4520 mL | 1.1300 mL | |
| 30 mM | 0.0377 mL | 0.1883 mL | 0.3767 mL | 0.9416 mL | |
| 40 mM | 0.0282 mL | 0.1412 mL | 0.2825 mL | 0.7062 mL | |
| 50 mM | 0.0226 mL | 0.1130 mL | 0.2260 mL | 0.5650 mL | |
| 60 mM | 0.0188 mL | 0.0942 mL | 0.1883 mL | 0.4708 mL | |
| 80 mM | 0.0141 mL | 0.0706 mL | 0.1412 mL | 0.3531 mL | |
| 100 mM | 0.0113 mL | 0.0565 mL | 0.1130 mL | 0.2825 mL |
PROTAC SARS-CoV-2 3CLPro degrader 2 Related Classifications
HY-161177 Related Classifications
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