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Cat. No.: HY-115907A

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(rac)-K20

(rac)-K20 is the racemate of K20, a KRas G12C inhibitor with an IC₅₀ of 1.16 μM. K20 has antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 2915618-92-5
Formula: C₂₄H₂₀Cl₂F₄N₄O₂
Molecular Weight:543.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

(rac)-K20 Chemical Structure

CAS No.: 2915618-92-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

(rac)-K20 is the racemate of K20, a KRas G12C inhibitor with an IC₅₀ of 1.16 μM. K20 has antitumor activity^[1].

Chemical Information

CAS No. 2915618-92-5
Molecular Weight 543.34
Formula C₂₄H₂₀Cl₂F₄N₄O₂
SMILES

C=C(C(N1CCN(C(C1)C)C2=NC=NC3=C(C(C4=CC(Cl)=CC=C4OC)=C(C=C23)Cl)F)=O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao H, et al. Discovery of ARS-1620 analogs as KRas G12C inhibitors with high in vivo antitumor activity. Bioorg Chem. 2022 Apr;121:105652. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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