KRAS inhibitor-14
KRAS inhibitor-14 (compound 3-22) is a potent KRAS G12C inhibitor with an IC50 of 0.249 µM. KRAS inhibitor-14 shows p-ERK inhibition activities with IC50s of 1.12, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-14 has the potential for the research of pancreatic, colorectal, and lung cancers.
For research use only. We do not sell to patients.
- CAS No.: 2230873-78-4
- Formula: C20H15Cl3FN3O2S
- Molecular Weight:486.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KRas G12C 0.249 μM (IC50) |
Chemical Information
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CAS No. 2230873-78-4
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Molecular Weight 486.77
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Formula C20H15Cl3FN3O2S
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SMILES
C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(O)=CC(Cl)=C4Cl)=C(C3=NS2)F)Cl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS inhibitor-14 Related Classifications
HY-146544 Related Classifications
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