1. PROTAC
    GPCR/G Protein
  2. Target Protein Ligand-Linker Conjugate
    Ras
  3. MRTX849 ethoxypropanoic acid

MRTX849 ethoxypropanoic acid 

Cat. No.: HY-139403
Handling Instructions

MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (DC50s between 0.25 and 0.76 μM).

For research use only. We do not sell to patients.

MRTX849 ethoxypropanoic acid Chemical Structure

MRTX849 ethoxypropanoic acid Chemical Structure

CAS No. : 2561529-98-2

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Description

MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (DC50s between 0.25 and 0.76 μM)[1][2].

IC50 & Target[1]

KRas G12C

 

Molecular Weight

720.23

Formula

C₃₇H₄₃ClFN₇O₅

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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MRTX849 ethoxypropanoic acid
Cat. No.:
HY-139403
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