2561529-98-2
Chemical Structure
MRTX849 ethoxypropanoic acid
- CAS No.: 2561529-98-2
- Formula:C37H43ClFN7O5
- Molecular Weight:720.23
IUPAC Name: 3-(3-((S)-2-(((7-(8-chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanoic acid
InChIKey: MCHXOHQIEJIIKB-NSOVKSMOSA-N
SMILES: O=C(N1CCN(C2=C3CCN(CC3=NC(OC[C@@H]4CCCN4CCCOCCC(O)=O)=N2)C5=CC=CC6=C5C(Cl)=CC=C6)C[C@@H]1CC#N)C(F)=C
Biological Activity: MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (IC50s between 0.25 and 0.76 μM)[1][2].
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MRTX849 ethoxypropanoic acid | MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (IC50s between 0.25 and 0.76 μM). | |||||||||||||||||||||
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Keywords
