2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRpep-2d TFA

KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

KRpep-2d TFA Chemical Structure

KRpep-2d TFA Chemical Structure

Size Price Stock Quantity
2 mg USD 120 In-stock
5 mg USD 230 In-stock
10 mg USD 380 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of KRpep-2d TFA:

KRpep-2d TFA Related Antibodies

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K-Ras H-Ras Ras

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1].

IC50 & Target[1]

K-RAS

 

In Vitro

KRpep-2d (TFA) has cyclic structure with importance for K-Ras inhibitory activity. Leu77 , Ile9 , and Asp12 are critical amino acid residues for the K-Ras inhibitory activity of KRpep-2d[1].
KRpep-2d (TFA) (10-30 μM) has inhibitory activity of A427 cells with the proliferation rates of 68.3% (10 μM) and 48.3% (10 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KRpep-2d TFA Related Antibodies
Molecular Weight

2675.03

Formula

C110H183F3N44O27S2
Appearance

Solid

Color

White to off-white

Sequence Shortening

Ac-RRRRCPLYISYDPVCRRRR-NH2 (disulfide bridge: Cys5-Cys15)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (37.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3738 mL 1.8691 mL 3.7383 mL
5 mM 0.0748 mL 0.3738 mL 0.7477 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (18.69 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.3738 mL 1.8691 mL 3.7383 mL 9.3457 mL
5 mM 0.0748 mL 0.3738 mL 0.7477 mL 1.8691 mL
10 mM 0.0374 mL 0.1869 mL 0.3738 mL 0.9346 mL
15 mM 0.0249 mL 0.1246 mL 0.2492 mL 0.6230 mL
20 mM 0.0187 mL 0.0935 mL 0.1869 mL 0.4673 mL
25 mM 0.0150 mL 0.0748 mL 0.1495 mL 0.3738 mL
30 mM 0.0125 mL 0.0623 mL 0.1246 mL 0.3115 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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KRpep-2d TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRpep-2dRasK-RasG12Dmutant selectiveanticancerInhibitorinhibitorinhibit

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