country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-176787

Copy Link Print Information

KRAS G12C Ligand-Linker Conjugates 1

KRAS G12C Ligand-Linker Conjugates 1 is a conjugate of KRAS^G12C ligand and linker, which can be used in the synthesis of PROTAC YF135 (HY-144323).

For research use only. We do not sell to patients.

CAS No.: 3033236-98-2
Formula: C₄₅H₅₅ClN₈O₅
Molecular Weight:823.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

KRAS G12C Ligand-Linker Conjugates 1 Chemical Structure

CAS No.: 3033236-98-2

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

KRAS G12C Ligand-Linker Conjugates 1 is a conjugate of KRAS^G12C ligand and linker, which can be used in the synthesis of PROTAC YF135 (HY-144323)^[1].

All Ras Isoforms :

Chemical Information

CAS No. 3033236-98-2
Molecular Weight 823.42
Formula C₄₅H₅₅ClN₈O₅
SMILES

O=C(CCOCCCN1CCC[C@H]1COC2=NC3=C(C(N4CCN([C@H](C4)CC#N)C(/C(C#N)=C/C5CC5)=O)=N2)CCN(C3)C6=CC=CC7=C6C(Cl)=CC=C7)OC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang F, et al. Efficient targeted oncogenic KRASG12C degradation via first reversible-covalent PROTAC. Eur J Med Chem. 2022 Feb 15;230:114088. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

KRAS G12C Ligand-Linker Conjugates 1

100 mg Get Quote

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

KRAS G12C Ligand-Linker Conjugates 1

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KRAS G12C Ligand-Linker Conjugates 1 Related Classifications

HY-176787 Related Classifications

Bioz