2. PROTAC TGF-beta/Smad Stem Cell/Wnt Metabolic Enzyme/Protease
  3. PROTACs TGF-beta/Smad HIF/HIF Prolyl-Hydroxylase
  4. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine 

Cat. No.: HY-147025 Purity: 99.06%
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(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual target PROTAC that can not only target to the ubiquitination and degradation of Smad3 but also improve the HIF-α protein level. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine has a multi-path anti-fibrosis function and a renal protection function for research of renal anemia.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine Chemical Structure

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine Chemical Structure

CAS No. : 2347517-69-3

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1 mg USD 90 In-stock
5 mg USD 260 In-stock
10 mg USD 380 In-stock
25 mg USD 800 In-stock
50 mg USD 1280 In-stock
100 mg USD 2100 In-stock
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Based on 2 publication(s) in Google Scholar

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

WB

    (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2023 Feb 2;gkad043.  [Abstract]

    (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine (The SMAD3 PROTAC inhibitor; 10, 20, 50 µM; 24 h) reduces levels of SMAD3 protein in Rv1 cells with concomitant reduction in the levels of AR, AR-V7 and AR targets.

    View All PROTACs Isoform Specific Products:

    View All Isoforms
    von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

    View All HIF/HIF Prolyl-Hydroxylase Isoform Specific Products:

    View All Isoforms
    HIF-1α HIF

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual target PROTAC that can not only target to the ubiquitination and degradation of Smad3 but also improve the HIF-α protein level. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine has a multi-path anti-fibrosis function and a renal protection function for research of renal anemia[1].

    Molecular Weight

    750.91

    Formula

    C41H46N6O6S
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCC(NC(C4=CN=CC=C4)C5=CC6=CC=CC=C6O5)=O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 170 mg/mL (226.39 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3317 mL 6.6586 mL 13.3172 mL
    5 mM 0.2663 mL 1.3317 mL 2.6634 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.3317 mL 6.6586 mL 13.3172 mL 33.2929 mL
    5 mM 0.2663 mL 1.3317 mL 2.6634 mL 6.6586 mL
    10 mM 0.1332 mL 0.6659 mL 1.3317 mL 3.3293 mL
    15 mM 0.0888 mL 0.4439 mL 0.8878 mL 2.2195 mL
    20 mM 0.0666 mL 0.3329 mL 0.6659 mL 1.6646 mL
    25 mM 0.0533 mL 0.2663 mL 0.5327 mL 1.3317 mL
    30 mM 0.0444 mL 0.2220 mL 0.4439 mL 1.1098 mL
    40 mM 0.0333 mL 0.1665 mL 0.3329 mL 0.8323 mL
    50 mM 0.0266 mL 0.1332 mL 0.2663 mL 0.6659 mL
    60 mM 0.0222 mL 0.1110 mL 0.2220 mL 0.5549 mL
    80 mM 0.0166 mL 0.0832 mL 0.1665 mL 0.4162 mL
    100 mM 0.0133 mL 0.0666 mL 0.1332 mL 0.3329 mL
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    (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine2347517-69-3PROTACsTGF-beta/SmadHIF/HIF Prolyl-HydroxylaseTransforming growth factor betaHypoxia-inducible factorsHIFsHIF-PHPROTACubiquitinationSmad3HIF-αanti-fibrosis functionrenal anemiaInhibitorinhibitorinhibit

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