country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-147025

Copy Link Print Information

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

Name: (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
Brand: MedChemExpress
SKU: HY-147025
Price: 90.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual-targeting PROTAC molecule. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine not only targets the ubiquitination and degradation of Smad3, but also elevates the protein level of HIF-α, thereby exerting multi-pathway anti-fibrotic and renoprotective effects. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can be used in a wide range of tumor studies including cancers with KRAS inhibitor resistance, covering pancreatic ductal adenocarcinoma, acute myeloid leukemia, and various soft tissue sarcomas (such as fibrosarcoma, liposarcoma, chondrosarcoma, etc.). (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can also be applied to research related to various solid tumors and hematological malignancies, involving multiple cancer types such as colon cancer, breast cancer, ovarian cancer, non-small cell lung cancer, glioblastoma, and melanoma.
(Pink: Smad3 Target protein ligand; Blue: VHL ligand (HY-112078); Black: linker).

For research use only. We do not sell to patients.

Purity : 98.62%
CAS No.: 2347517-69-3
Formula: C₄₁H₄₆N₆O₆S
Molecular Weight:750.91

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine Chemical Structure

CAS No.: 2347517-69-3

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-130271
(S,R,S)-AHPC-PEG5-COOH

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual-targeting PROTAC molecule. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine not only targets the ubiquitination and degradation of Smad3, but also elevates the protein level of HIF-α, thereby exerting multi-pathway anti-fibrotic and renoprotective effects. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can be used in a wide range of tumor studies including cancers with KRAS inhibitor resistance, covering pancreatic ductal adenocarcinoma, acute myeloid leukemia, and various soft tissue sarcomas (such as fibrosarcoma, liposarcoma, chondrosarcoma, etc.). (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can also be applied to research related to various solid tumors and hematological malignancies, involving multiple cancer types such as colon cancer, breast cancer, ovarian cancer, non-small cell lung cancer, glioblastoma, and melanoma^[1]. (Pink: Smad3 Target protein ligand; Blue: VHL ligand (HY-112078); Black: linker).

IC₅₀ & Target

^[1]

VHL

Smad3

All PROTACs Isoforms :

All TGF-beta/Smad Isoforms :

Smad1
Smad3

All HIF/HIF Prolyl-Hydroxylase Isoforms :

In Vitro

Smad3 is a key transcription factor in the TGF-β signaling pathway, involved in processes such as cell proliferation, differentiation, and fibrosis. Selective degradation of Smad3 avoids the interference with the Smad4 pathway often associated with traditional inhibition methods, offering a novel approach for treating fibrotic diseases and cancer.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

CWR22Rv1 cells
Concentration:

0, 10, 20 and 50 μM
Incubation Time:

24 h
Result:

Significantly reduced the protein levels of Smad3, AR, AR-V7.

RT-PCR^[2]

Cell Line:

CWR22Rv1 cells
Concentration:

0, 10, 20 and 50 μM
Incubation Time:

24 h
Result:

Significantly reduced the mRNA levels of Smad3, AR, AR-V7.

Chemical Information

CAS No. 2347517-69-3
Appearance Solid
Molecular Weight 750.91
Formula C₄₁H₄₆N₆O₆S
Color White to light yellow
SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCC(NC(C4=CN=CC=C4)C5=CC6=CC=CC=C6O5)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

All WB

Sort by:

Journal Impact Factor

Nucleic Acids Res

SMAD3 promotes expression and activity of the androgen receptor in prostate cancer. [Abstract]

2023 Apr 11;51(6):2655-2670. PMID: 36727462

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2023 Apr 11;51(6):2655-2670. [Abstract]

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine (The SMAD3 PROTAC inhibitor; 10, 20, 50 µM; 24 h) reduces levels of SMAD3 protein in Rv1 cells with concomitant reduction in the levels of AR, AR-V7 and AR targets.

Solvent & Solubility

In Vitro:

DMSO : ≥ 170 mg/mL (226.39 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3317 mL

6.6586 mL

13.3172 mL

5 mM

0.2663 mL

1.3317 mL

2.6634 mL

10 mM

0.1332 mL

0.6659 mL

1.3317 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (293 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pingping Hou, et al. Compositions and methods for use in kras-targeted therapies for the treatment of cancer. US20250339520A1. 2025-05-01.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.3317 mL	6.6586 mL	13.3172 mL	33.2929 mL
	5 mM	0.2663 mL	1.3317 mL	2.6634 mL	6.6586 mL
	10 mM	0.1332 mL	0.6659 mL	1.3317 mL	3.3293 mL
	15 mM	0.0888 mL	0.4439 mL	0.8878 mL	2.2195 mL
	20 mM	0.0666 mL	0.3329 mL	0.6659 mL	1.6646 mL
	25 mM	0.0533 mL	0.2663 mL	0.5327 mL	1.3317 mL
	30 mM	0.0444 mL	0.2220 mL	0.4439 mL	1.1098 mL
	40 mM	0.0333 mL	0.1665 mL	0.3329 mL	0.8323 mL
	50 mM	0.0266 mL	0.1332 mL	0.2663 mL	0.6659 mL
	60 mM	0.0222 mL	0.1110 mL	0.2220 mL	0.5549 mL
	80 mM	0.0166 mL	0.0832 mL	0.1665 mL	0.4162 mL
	100 mM	0.0133 mL	0.0666 mL	0.1332 mL	0.3329 mL

Bioz

Keywords

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

1 Cited Publications

100 mg Get Quote

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

1/16
1/16

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2023 Apr 11;51(6):2655-2670. [Abstract]

Customer Validation
(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine (The SMAD3 PROTAC inhibitor; 10, 20, 50 µM; 24 h) reduces levels of SMAD3 protein in Rv1 cells with concomitant reduction in the levels of AR, AR-V7 and AR targets.

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

Publications Citing Use of MedChemExpress (MCE) (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

All PROTACs Isoforms

All TGF-beta/Smad Isoforms

All HIF/HIF Prolyl-Hydroxylase Isoforms