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Cat. No.: HY-159611

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KRAS G12C inhibitor 68

KRAS G12C inhibitor 68 (compound I-063) is a KRAS G12C inhibitor with an IC₅₀ of 7 nM. KRAS G12C inhibitor 68 has anti-tumor activity.

For research use only. We do not sell to patients.

CAS No.: 3034851-27-6
Formula: C₃₅H₄₄F₂N₆O₃
Molecular Weight:634.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

KRAS G12C inhibitor 68 Chemical Structure

CAS No.: 3034851-27-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

KRAS G12C inhibitor 68 (compound I-063) is a KRAS G12C inhibitor with an IC₅₀ of 7 nM. KRAS G12C inhibitor 68 has anti-tumor activity^[1].

IC₅₀ & Target

KRas G12C

7 nM (IC₅₀)

All Ras Isoforms :

Chemical Information

CAS No. 3034851-27-6
Molecular Weight 634.76
Formula C₃₅H₄₄F₂N₆O₃
SMILES

FC(C1=C2C(N3[C@](CC=C2)([H])[C@H](N4CCN(CC4)C(C=C)=O)C3)=CC(N5[C@@H](C[C@@H](C6=C(C7(COC7)OC)N=CC=C6C)CC5)C)=N1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Brian A. Lanman, et al. Tethered heterocyclic inhibitors of kras g12c mutant proteins and uses thereof. WO2024076670A3.2024-05-30.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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KRAS G12C inhibitor 68

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KRAS G12C inhibitor 68 Related Classifications

HY-159611 Related Classifications