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Cat. No.: HY-181733

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KRAS G12D ligand-3

KRAS G12D ligand-3 is a KRAS G12D PROTAC ligand. KRAS G12D ligand-3 can be conjugated with E3 ligase Ligand (HY-170348) and linke (HY-W895436) to synthesize KRAS G12D PROTAC degrader MS243 (HY-181728). MS243 can be used for cancer research.

For research use only. We do not sell to patients.

Formula: C₃₃H₃₂F₂N₆O₄
Molecular Weight:614.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS G12D ligand-3 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

KRas G12D

All Ras Isoforms :

Chemical Information

Molecular Weight 614.64
Formula C₃₃H₃₂F₂N₆O₄
SMILES

FC(C=C1)=C(C#C)C(C1=CC(O)=C2)=C2C3=NC=C4C(N=C(OC[C@H]5N(CCC(O)=O)CCC5)N=C4N6C[C@H]7N[C@H](CC7)C6)=C3F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yim H, et al. Discovery of KRAS-G12D degraders via exploration of various E3 ligases. Eur J Med Chem. 2026;307:118635. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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