2. PROTAC
  3. Ligands for E3 Ligase
  4. (S)-(S,R,S,R)-AHPC-Me-N3

(S)-(S,R,S,R)-AHPC-Me-N3 serves as the E3 ligase ligand for PROTAC SMARCA2 degrader-32 (HY-170343) and can be used in the synthesis of PROTACs.

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(S)-(S,R,S,R)-AHPC-Me-N3

(S)-(S,R,S,R)-AHPC-Me-N3 構造式

CAS 番号 : 2958620-43-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 49 在庫あり
Solution
10 mM * 1 mL in DMSO USD 49 在庫あり
Solid
5 mg $47 在庫あり
10 mg $74 在庫あり
25 mg $148 在庫あり
50 mg $236 在庫あり
100 mg $378 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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(S)-(S,R,S,R)-AHPC-Me-N3 関連抗体

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Ligands for E3 Ligase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 SPOP DCAF1 UHRF1 TRIM21 NEURL1B KLHL41 RNF114 DDB1 FEM1B

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製品説明

(S)-(S,R,S,R)-AHPC-Me-N3 serves as the E3 ligase ligand for PROTAC SMARCA2 degrader-32 (HY-170343) and can be used in the synthesis of PROTACs[1].

IC50 & Target

VHL

 

分子量

470.59

分子式

C23H30N6O3S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)N=[N+]=[N-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 25 mg/mL (53.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1250 mL 10.6250 mL 21.2499 mL
5 mM 0.4250 mL 2.1250 mL 4.2500 mL
10 mM 0.2125 mL 1.0625 mL 2.1250 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1250 mL 10.6250 mL 21.2499 mL 53.1248 mL
5 mM 0.4250 mL 2.1250 mL 4.2500 mL 10.6250 mL
10 mM 0.2125 mL 1.0625 mL 2.1250 mL 5.3125 mL
15 mM 0.1417 mL 0.7083 mL 1.4167 mL 3.5417 mL
20 mM 0.1062 mL 0.5312 mL 1.0625 mL 2.6562 mL
25 mM 0.0850 mL 0.4250 mL 0.8500 mL 2.1250 mL
30 mM 0.0708 mL 0.3542 mL 0.7083 mL 1.7708 mL
40 mM 0.0531 mL 0.2656 mL 0.5312 mL 1.3281 mL
50 mM 0.0425 mL 0.2125 mL 0.4250 mL 1.0625 mL
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(S)-(S,R,S,R)-AHPC-Me-N3 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-(S,R,S,R)-AHPC-Me-N32958620-43-2Ligands for E3 LigaseE3 ligase-recruiting MoietyPROTACsInhibitorinhibitorinhibit

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製品名:
(S)-(S,R,S,R)-AHPC-Me-N3
製品番号:
HY-170348
数量:
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