MRTX849 analog 24
Based on 1 Customer Validation
MRTX849 analog 24 is a KRASG12C inhibitor with a human IC50 of 140 nM. MRTX849 analog 24 binds to KRASG12C, forms a covalent interaction, and acts as a click probe to bait the protein target in proteomic studies. MRTX849 analog 24 exhibits cellular activity in cancer cells. MRTX849 analog 24 can be used for the research of krasG12C-mutant cancer.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 2490716-96-4
- Formula: C36H39ClFN7O2
- Molecular Weight:656.19
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KRAS(G12C) 40 nM (IC50) |
MRTX849 analog 24 (Compound 24) (3 h) inhibits phospho-ERK in KRASG12C-harboring NCI-H358 cells with a cellular IC50 of 140 nM following 3 h of incubation[1].
MRTX849 analog 24 (2 μM; 3 h), used as a click probe in NCI-H358 cells, confirms high selectivity of MRTX849 for KRASG12C, as only KRASG12C shows reduced probe binding after MRTX849 pre-treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2490716-96-4
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Appearance Solid
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Molecular Weight 656.19
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Formula C36H39ClFN7O2
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Color White to off-white
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SMILES
N#CC[C@@H]1N(C(C(F)=C)=O)CCN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(CCCC#C)CCC6)=N2)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (76.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (288 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5239 mL | 7.6197 mL | 15.2395 mL | 38.0987 mL |
| 5 mM | 0.3048 mL | 1.5239 mL | 3.0479 mL | 7.6197 mL | |
| 10 mM | 0.1524 mL | 0.7620 mL | 1.5239 mL | 3.8099 mL | |
| 15 mM | 0.1016 mL | 0.5080 mL | 1.0160 mL | 2.5399 mL | |
| 20 mM | 0.0762 mL | 0.3810 mL | 0.7620 mL | 1.9049 mL | |
| 25 mM | 0.0610 mL | 0.3048 mL | 0.6096 mL | 1.5239 mL | |
| 30 mM | 0.0508 mL | 0.2540 mL | 0.5080 mL | 1.2700 mL | |
| 40 mM | 0.0381 mL | 0.1905 mL | 0.3810 mL | 0.9525 mL | |
| 50 mM | 0.0305 mL | 0.1524 mL | 0.3048 mL | 0.7620 mL | |
| 60 mM | 0.0254 mL | 0.1270 mL | 0.2540 mL | 0.6350 mL |
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