2490716-96-4
Chemical Structure
MRTX849 analog 24
- CAS No.: 2490716-96-4
- Formula:C36H39ClFN7O2
- Molecular Weight:656.19
IUPAC Name: 2-((S)-4-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-(pent-4-yn-1-yl)pyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile
InChIKey: YUPCFANWZUHYAJ-NSOVKSMOSA-N
SMILES: N#CC[C@@H]1N(C(C(F)=C)=O)CCN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(CCCC#C)CCC6)=N2)C1
Biological Activity: MRTX849 analog 24 is a KRASG12C inhibitor with a human IC50 of 140 nM. MRTX849 analog 24 binds to KRASG12C, forms a covalent interaction, and acts as a click probe to bait the protein target in proteomic studies. MRTX849 analog 24 exhibits cellular activity in cancer cells. MRTX849 analog 24 can be used for the research of krasG12C-mutant cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MRTX849 analog 24 | 98.01% | MRTX849 analog 24 is a KRASG12C inhibitor with a human IC50 of 140 nM. MRTX849 analog 24 binds to KRASG12C, forms a covalent interaction, and acts as a click probe to bait the protein target in proteomic studies. MRTX849 analog 24 exhibits cellular activity in cancer cells. MRTX849 analog 24 can be used for the research of krasG12C-mutant cancer. | ||||||||||||||||||||
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Keywords
