KRAS G12C inhibitor 48
KRAS G12C inhibitor 48 (compound 6e) is a potent KRAS G12C inhibitor with an IC50 of 639.91 nM. KRAS G12C inhibitor 48 (0-50 µM) shows anti-proliferative activity with IC50s of 0.796, 6.33, 16.14 µM for H358, H23, A549 cells, respectively.
For research use only. We do not sell to patients.
- CAS No.: 3033236-94-8
- Formula: C36H39ClN8O2
- Molecular Weight:651.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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KRas G12C 639.91 nM (IC50) |
Chemical Information
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CAS No. 3033236-94-8
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Molecular Weight 651.20
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Formula C36H39ClN8O2
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SMILES
N#C/C(C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)CC1)=O)=C\C7CC7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)