2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12C inhibitor 48

KRAS G12C inhibitor 48 (compound 6e) is a potent KRAS G12C inhibitor with an IC50 of 639.91 nM. KRAS G12C inhibitor 48 (0-50 µM) shows anti-proliferative activity with IC50s of 0.796, 6.33, 16.14 µM for H358, H23, A549 cells, respectively.

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KRAS G12C inhibitor 48 Chemical Structure

KRAS G12C inhibitor 48 Chemical Structure

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KRAS G12C inhibitor 48 Related Antibodies

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Description

KRAS G12C inhibitor 48 (compound 6e) is a potent KRAS G12C inhibitor with an IC50 of 639.91 nM. KRAS G12C inhibitor 48 (0-50 µM) shows anti-proliferative activity with IC50s of 0.796, 6.33, 16.14 µM for H358, H23, A549 cells, respectively[1].

IC50 & Target

KRas G12C

639.91 nM (IC50)

Molecular Weight

651.20

Formula

C36H39ClN8O2
SMILES

N#C/C(C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)CC1)=O)=C\C7CC7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KRAS G12C inhibitor 48 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12C inhibitor 48Rasanti-proliferativeH358H23A549 cellsanticancerInhibitorinhibitorinhibit

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