3033236-94-8
Chemical Structure
KRAS G12C inhibitor 48
- CAS No.: 3033236-94-8
- Formula:C36H39ClN8O2
- Molecular Weight:651.20
IUPAC Name: (E)-2-((S)-4-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-2-(cyanomethyl)piperazine-1-carbonyl)-3-cyclopropylacrylonitrile
InChIKey: CROGWWKTKKFIJR-YUWSGBISSA-N
SMILES: N#C/C(C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)CC1)=O)=C\C7CC7
Biological Activity: KRAS G12C inhibitor 48 (compound 6e) is a potent KRAS G12C inhibitor with an IC50 of 639.91 nM. KRAS G12C inhibitor 48 (0-50 µM) shows anti-proliferative activity with IC50s of 0.796, 6.33, 16.14 µM for H358, H23, A549 cells, respectively[1].
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KRAS G12C inhibitor 48 | KRAS G12C inhibitor 48 (compound 6e) is a potent KRAS G12C inhibitor with an IC50 of 639.91 nM. KRAS G12C inhibitor 48 (0-50 µM) shows anti-proliferative activity with IC50s of 0.796, 6.33, 16.14 µM for H358, H23, A549 cells, respectively. | |||||||||||||||||||||
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Keywords
