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Cat. No.: HY-163488

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KRASG12D-IN-4

KRASG12D-IN-4 (example 38) is a KRas^G12D inhibitor with an IC₅₀ of 3.3 nM. KRASG12D-IN-4 inhibits proliferation of pancreatic cancer ASPC-1 cells with an IC₅₀ of 12 nM.

For research use only. We do not sell to patients.

CAS No.: 3034052-35-9
Formula: C₃₅H₃₁F₃N₆O₂
Molecular Weight:624.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

KRASG12D-IN-4 Chemical Structure

CAS No.: 3034052-35-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

KRASG12D-IN-4 (example 38) is a KRas^G12D inhibitor with an IC₅₀ of 3.3 nM. KRASG12D-IN-4 inhibits proliferation of pancreatic cancer ASPC-1 cells with an IC₅₀ of 12 nM^[1].

IC₅₀ & Target^[1]

KRas G12D

3.3 nM (IC₅₀)

All Ras Isoforms :

Chemical Information

CAS No. 3034052-35-9
Molecular Weight 624.65
Formula C₃₅H₃₁F₃N₆O₂
SMILES

CC#CC1=C2C(N3CC4CC(N4)C3)=NC(OC[C@@]56CCCN5C[C@@H](C6)F)=NC2=C(C(C7=CC(O)=CC8=C7C(C#C)=C(C=C8)F)=N1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lei Y et al. Kras mutant protein inhibitor, preparation method therefor, and use thereof. PCT Int. (2024), WO2024061333A1

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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KRASG12D-IN-4

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KRASG12D-IN-4 Related Classifications

HY-163488 Related Classifications