2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. PPI stabilizer-1

PPI stabilizer-1-1 (Compound 2) is a KRAS dimerizing agent. PPI stabilizer-1-1 dimerizes KRAS with a KD of 3.8 µM. PPI stabilizer-1-1 co-crystallizes with GCP-KRASG12D. PPI stabilizer-1 can be used for the research of KRAS-driven cancers.

For research use only. We do not sell to patients.

PPI stabilizer-1

PPI stabilizer-1 Chemical Structure

CAS No. : 2429876-60-6

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PPI stabilizer-1 Related Antibodies

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Description

PPI stabilizer-1-1 (Compound 2) is a KRAS dimerizing agent. PPI stabilizer-1-1 dimerizes KRAS with a KD of 3.8 µM. PPI stabilizer-1-1 co-crystallizes with GCP-KRASG12D. PPI stabilizer-1 can be used for the research of KRAS-driven cancers[1].

IC50 & Target[1]

KRas G12D

 

In Vitro

PPI stabilizer-1 dimerizes KRAS with a KD of 3.8 µM according to isothermal calorimetry measurements[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PPI stabilizer-1 Related Antibodies
Molecular Weight

668.78

Formula

C40H40N6O4
CAS No.
SMILES

O=C(N1)C(C([C@H]1C(C2=CC=CC=C2N3)=C3CNCCCCCCNCC4=C([C@@H]5C6=CC(O)=CC=C6C(N5)=O)C7=CC=CC=C7N4)=C8)=CC=C8O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PPI stabilizer-1 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPI stabilizer-12429876-60-6PPI stabilizer1PPI stabilizer 1Rasextended β-sheet interface dimeric conformationGCP-KRASG12DKRASG12Disothermal calorimetryβ-sandwich interface KRAS dimerKRAS dimerizationkras-driven cancersInhibitorinhibitorinhibit

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