1. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway JAK/STAT Signaling Epigenetics Stem Cell/Wnt
  2. Src VEGFR p38 MAPK JAK
  3. AMG-47a

AMG-47a is a potent and orally active lymphocyte-specific protein tyrosine kinase (Lck) inhibitor, with an IC50 of 0.2 nM. AMG-47a also inhibits VEGF2, p38α, Jak3 and MLR and IL-2 with IC50s of 1 nM, 3 nM, 72 nM, 30 nM and 21 nM, respectively. AMG-47a has anti-inflammatory activity.

For research use only. We do not sell to patients.

AMG-47a Chemical Structure

AMG-47a Chemical Structure

CAS No. : 882663-88-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 130 In-stock
Solution
10 mM * 1 mL in DMSO USD 130 In-stock
Solid
5 mg USD 110 In-stock
10 mg USD 190 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    AMG-47a purchased from MedChemExpress. Usage Cited in: Oncogene. 2018 Aug;37(31):4226-4238.  [Abstract]

    AMG-47 results in decreased ERK phosphorylation.

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    • Biological Activity

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    Description

    AMG-47a is a potent and orally active lymphocyte-specific protein tyrosine kinase (Lck) inhibitor, with an IC50 of 0.2 nM. AMG-47a also inhibits VEGF2, p38α, Jak3 and MLR and IL-2 with IC50s of 1 nM, 3 nM, 72 nM, 30 nM and 21 nM, respectively. AMG-47a has anti-inflammatory activity[1].

    IC50 & Target

    IC50: 0.2 nM (Lck), 1 nM (VEGF2), 3 nM (p38α), 72 nM (Jak3), 30 nM (MLR), 21 nM (IL-2)[1]

    Molecular Weight

    535.56

    Formula

    C29H28F3N5O2

    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(C3=CC4=CN=C(NCCN5CCOCC5)N=C4C=C3)=C2

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 34 mg/mL (63.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8672 mL 9.3360 mL 18.6720 mL
    5 mM 0.3734 mL 1.8672 mL 3.7344 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.8672 mL 9.3360 mL 18.6720 mL 46.6801 mL
    5 mM 0.3734 mL 1.8672 mL 3.7344 mL 9.3360 mL
    10 mM 0.1867 mL 0.9336 mL 1.8672 mL 4.6680 mL
    15 mM 0.1245 mL 0.6224 mL 1.2448 mL 3.1120 mL
    20 mM 0.0934 mL 0.4668 mL 0.9336 mL 2.3340 mL
    25 mM 0.0747 mL 0.3734 mL 0.7469 mL 1.8672 mL
    30 mM 0.0622 mL 0.3112 mL 0.6224 mL 1.5560 mL
    40 mM 0.0467 mL 0.2334 mL 0.4668 mL 1.1670 mL
    50 mM 0.0373 mL 0.1867 mL 0.3734 mL 0.9336 mL
    60 mM 0.0311 mL 0.1556 mL 0.3112 mL 0.7780 mL
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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