1. Protein Tyrosine Kinase/RTK
    MAPK/ERK Pathway
    Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. Src
    VEGFR
    p38 MAPK
    JAK
  3. AMG-47a

AMG-47a 

Cat. No.: HY-18303 Purity: 98.71%
Handling Instructions

AMG-47a is a potent and orally bioavailable lymphocyte-specific protein tyrosine kinase (Lck) inhibitor, with an IC50 of 0.2 nM. AMG-47a also inhibits VEGF2,p38α, Jak3 and MLR and IL-2 with IC50s of 1 nM, 3 nM, 72 nM, 30 nM and 21 nM, respectively. AMG-47a has anti-inflammatory activity.

For research use only. We do not sell to patients.

AMG-47a Chemical Structure

AMG-47a Chemical Structure

CAS No. : 882663-88-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 212 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 312 In-stock
Estimated Time of Arrival: December 31
25 mg USD 720 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE AMG-47a

    AMG-47a purchased from MCE. Usage Cited in: Oncogene. 2018 Aug;37(31):4226-4238.

    AMG-47 results in decreased ERK phosphorylation.

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    Description

    AMG-47a is a potent and orally bioavailable lymphocyte-specific protein tyrosine kinase (Lck) inhibitor, with an IC50 of 0.2 nM. AMG-47a also inhibits VEGF2,p38α, Jak3 and MLR and IL-2 with IC50s of 1 nM, 3 nM, 72 nM, 30 nM and 21 nM, respectively. AMG-47a has anti-inflammatory activity[1].

    IC50 & Target

    IC50: 0.2 nM (Lck), 1 nM (VEGF2), 3 nM (p38α), 72 nM (Jak3), 30 nM (MLR), 21 nM (IL-2)[1]

    Molecular Weight

    535.56

    Formula

    C₂₉H₂₈F₃N₅O₂

    CAS No.

    882663-88-9

    SMILES

    O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(C3=CC4=CN=C(NCCN5CCOCC5)N=C4C=C3)=C2

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 34 mg/mL (63.48 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8672 mL 9.3360 mL 18.6720 mL
    5 mM 0.3734 mL 1.8672 mL 3.7344 mL
    10 mM 0.1867 mL 0.9336 mL 1.8672 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    AMG-47aSrcVEGFRp38 MAPKJAKVascular endothelial growth factor receptorJanus kinasecytoplamictyrosinekinasesfamilyTcellreceptorsignaltransductionspecificimmuneresponsesInhibitorinhibitorinhibit

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    Cat. No.:
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