2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. CDK Discoidin Domain Receptor Apoptosis Reactive Oxygen Species (ROS) DNA/RNA Synthesis
  4. CDK4/6/BRD4-IN-2

CDK4/6/BRD4-IN-2 (Compound PJ2) is a dual inhibitor of CDK4/6 and BRD4 with IC50 values for CDK4, CDK6, BRD4 (BD1), and BRD4 (BD2) of 168.75, 292.45, 23.17, and 3.12 nM respectively. CDK4/6/BRD4-IN-2 has a strong inhibitory effect on non-small cell lung cancer (NSCLC) cell lines. CDK4/6/BRD4-IN-2 induces cell cycle arrest, senescence and apoptosis through ROS-mediated DNA damage. CDK4/6/BRD4-IN-2 can also effectively inhibit the migration and invasion of NCI-H358 cells. CDK4/6-IN-2 can be used for the study of KRAS-mutated NSCLC.

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CDK4/6/BRD4-IN-2

CDK4/6/BRD4-IN-2 Chemical Structure

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CDK4/6/BRD4-IN-2 Related Antibodies

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DDR1 DDR2

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Description

CDK4/6/BRD4-IN-2 (Compound PJ2) is a dual inhibitor of CDK4/6 and BRD4 with IC50 values for CDK4, CDK6, BRD4 (BD1), and BRD4 (BD2) of 168.75, 292.45, 23.17, and 3.12 nM respectively. CDK4/6/BRD4-IN-2 has a strong inhibitory effect on non-small cell lung cancer (NSCLC) cell lines. CDK4/6/BRD4-IN-2 induces cell cycle arrest, senescence and apoptosis through ROS-mediated DNA damage. CDK4/6/BRD4-IN-2 can also effectively inhibit the migration and invasion of NCI-H358 cells. CDK4/6-IN-2 can be used for the study of KRAS-mutated NSCLC[1].

Molecular Weight

873.47

Formula

C45H49ClN12O3S
SMILES

CC(C1=CN=C(NC2=CC=C(N3CCN(CCNC(C[C@H]4C5=NN=C(C)N5C(SC(C)=C6C)=C6C(C7=CC=C(Cl)C=C7)=N4)=O)CC3)C=N2)N=C1N8C9CCCC9)=C(C(C)=O)C8=O
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Room temperature in continental US; may vary elsewhere.
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CDK4/6/BRD4-IN-2 Related Classifications

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Keywords:

CDK4/6/BRD4-IN-2CDKDiscoidin Domain ReceptorApoptosisReactive Oxygen Species (ROS)DNA/RNA SynthesisCyclin dependent kinaseCDK4/6BRD4KRAS-Mutant NSCLCSenescenceAntitumorDual inhibitorsPJ2Drug resistanceInhibitorinhibitorinhibit

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