K-Ras ligand-Linker Conjugate 1
K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.
For research use only. We do not sell to patients.
- CAS No.: 2749492-84-8
- Formula: C43H54N8O9
- Molecular Weight:826.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2749492-84-8
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Molecular Weight 826.94
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Formula C43H54N8O9
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SMILES
O=C(N1CCOCCOCCOCCO[C@@H]2C[C@@H](COC3=NC4=C(CCNC4)C(N5CCN(C(OCC6=CC=CC=C6)=O)[C@@H](CC#N)C5)=N3)N(C)C2)C7=C(C=CC=C7)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
K-Ras ligand-Linker Conjugate 1 Related Classifications
HY-129775 Related Classifications
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