2749492-84-8
Chemical Structure
K-Ras ligand-Linker Conjugate 1
- CAS No.: 2749492-84-8
- Formula:C43H54N8O9
- Molecular Weight:826.94
IUPAC Name: benzyl (S)-2-(cyanomethyl)-4-(2-(((2S,4R)-4-(2-(2-(2-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)ethoxy)ethoxy)ethoxy)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate
InChIKey: RLYCTEGJKCAPGP-DHWXLLNHSA-N
SMILES: O=C(N1CCOCCOCCOCCO[C@@H]2C[C@@H](COC3=NC4=C(CCNC4)C(N5CCN(C(OCC6=CC=CC=C6)=O)[C@@H](CC#N)C5)=N3)N(C)C2)C7=C(C=CC=C7)C1=O
Biological Activity: K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
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K-Ras ligand-Linker Conjugate 1 | K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells. | |||||||||||||||||||||
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Keywords
