KRAS inhibitor-22
KRAS inhibitor-22 (compound FB9/6B9) is a potent inhibitor of K-Ras. KRAS inhibitor-22 targets to Kras 4B(G12D) and (G12C), which can be used for cancer research.
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- CAS. Nr.: 2042365-57-9
- Formel: C23H21ClF4N2O5
- Molecular Weight:516.87
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
KRAS inhibitor-22 (8 μM; 24 h) degrades K-Ras induced by 25 ng/mL EGF, in MIAPaCa-2 cells (G12C) and in L3.6pl cells (G12D)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MIAPaCa-2 cells (G12C) and L3.6pl cells (G12D)
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Concentration:8 μM
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Incubation Time:7 min, 60 min, 24 h, 48 h
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Result:Degraded K-Ras (G12D) in L3.6pl cells during 24 h reeatment, but insignificantly at 48 h.
Degraded K-Ras (G12C) in MIAPaCa-2 cells during 48 h.
Chemical Information
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CAS. Nr. 2042365-57-9
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Molecular Weight 516.87
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Formel C23H21ClF4N2O5
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SMILES
O=C(N1C[C@H](CCC1)C(NCC(COC2=C(C(F)=CC(F)=C2F)F)=O)=O)C3=C(C=CC(Cl)=C3)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KRAS inhibitor-22 Related Classifications
HY-153412 Related Classifications
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