KRAS inhibitor-18
KRAS inhibitor-18 (compound 3-10) is a potent KRAS G12C inhibitor with an IC50 of 4.74 µM. KRAS inhibitor-18 shows p-ERK inhibition activities with IC50s of 66.4, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-18 has the potential for the research of pancreatic, colorectal, and lung cancers.
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- CAS. Nr.: 2230873-66-0
- Formel: C20H15ClF3N3O2S
- Molecular Weight:453.87
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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KRas G12C 4.74 μM (IC50) |
Chemical Information
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CAS. Nr. 2230873-66-0
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Molecular Weight 453.87
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Formel C20H15ClF3N3O2S
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SMILES
C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(O)=C(C=C4F)F)=C(C3=NS2)F)Cl)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KRAS inhibitor-18 Related Classifications
HY-146476 Related Classifications
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