2230873-66-0
2230873-66-0
Chemical Structure
KRAS inhibitor-18
- CAS No.: 2230873-66-0
- Formula:C20H15ClF3N3O2S
- Molecular Weight:453.87
IUPAC Name: 1-(4-(5-chloro-6-(2,4-difluoro-5-hydroxyphenyl)-7-fluorobenzo[c]isothiazol-3-yl)piperazin-1-yl)prop-2-en-1-one
InChIKey: NDGHIBDKESCHLI-UHFFFAOYSA-N
SMILES: C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(O)=C(C=C4F)F)=C(C3=NS2)F)Cl)=O
Biological Activity: KRAS inhibitor-18 (compound 3-10) is a potent KRAS G12C inhibitor with an IC50 of 4.74 µM. KRAS inhibitor-18 shows p-ERK inhibition activities with IC50s of 66.4, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-18 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
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KRAS inhibitor-18 | KRAS inhibitor-18 (compound 3-10) is a potent KRAS G12C inhibitor with an IC50 of 4.74 µM. KRAS inhibitor-18 shows p-ERK inhibition activities with IC50s of 66.4, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-18 has the potential for the research of pancreatic, colorectal, and lung cancers. | |||||||||||||||||||||
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