1. Metabolic Enzyme/Protease
  2. Farnesyl Transferase
  3. FTI 276 TFA

FTI 276 TFA 

Cat. No.: HY-15873A Purity: 98.06%
Handling Instructions

FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC50s of 0.9 nM and 0.5 nM for Plasmodium falciparum and human, respectively.

For research use only. We do not sell to patients.

FTI 276 TFA Chemical Structure

FTI 276 TFA Chemical Structure

CAS No. : 1217471-51-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 482 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 482 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of FTI 276 TFA:

Top Publications Citing Use of Products
  • Biological Activity

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  • Customer Review

Description

FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC50s of 0.9 nM and 0.5 nM for Plasmodium falciparum and human, respectively[1].

IC50 & Target

IC50: 0.9 nM (PFT, Plasmodium falciparum), 0.5 nM (PFT, human)[1].

Molecular Weight

547.61

Formula

C₂₃H₂₈F₃N₃O₅S₂

CAS No.
SMILES

O=C(O)[[email protected]@H](NC(C1=CC=C(NC[[email protected]@H](N)CS)C=C1C2=CC=CC=C2)=O)CCSC.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (182.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8261 mL 9.1306 mL 18.2612 mL
5 mM 0.3652 mL 1.8261 mL 3.6522 mL
10 mM 0.1826 mL 0.9131 mL 1.8261 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

FTI 276FTI276FTI-276Farnesyl TransferaseFtaseInhibitorinhibitorinhibit

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Product Name:
FTI 276 TFA
Cat. No.:
HY-15873A
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