2. Metabolic Enzyme/Protease
  3. Farnesyl Transferase
  4. FTI 276

FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC50s of 0.9 and 0.5 nM for Plasmodium falciparum and human.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (FTI 276 TFA) that retains the same biological activity.

For research use only. We do not sell to patients.

FTI 276

FTI 276 Chemical Structure

CAS No. : 170006-72-1

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FTI 276 Related Antibodies

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Description

FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC50s of 0.9 and 0.5 nM for Plasmodium falciparum and human.

IC50 & Target

IC50: 0.9 and 0.5 nM for Plasmodium falciparum and human[1].
Cellular Effect
Cell Line Type Value Description References
Caco-2 IC50
> 10000 nM
Compound: Hamilton FTI
Inhibition of human adenocarcinoma cell line Caco-2 proliferation
Inhibition of human adenocarcinoma cell line Caco-2 proliferation
[PMID: 11784156]
LoVo IC50
50 nM
Compound: Hamilton FTI
Inhibition of human adenocarcinoma cell line LoVo proliferation
Inhibition of human adenocarcinoma cell line LoVo proliferation
[PMID: 11784156]
NIH3T3 EC50
1 μM
Compound: 1
Inhibition of H-ras processing in subconfluent H-Ras-transformed NIH3T3 cells
Inhibition of H-ras processing in subconfluent H-Ras-transformed NIH3T3 cells
[PMID: 10201832]
NIH3T3 ED50
1 μM
Compound: 1
Inhibition of Ha-Ras processing in NIH3T3 Ras transformed cells.
Inhibition of Ha-Ras processing in NIH3T3 Ras transformed cells.
[PMID: 9784104]
NIH3T3 ED50
> 25 μM
Compound: FTI-276
Effective dose against murine 3T3 fibroblasts cells
Effective dose against murine 3T3 fibroblasts cells
[PMID: 14711313]
NIH3T3 IC50
1 μM
Compound: 1 (FTI-276)
Inhibition of mammalian H-Ras processing in NIH 3T3 cells
Inhibition of mammalian H-Ras processing in NIH 3T3 cells
[PMID: 11277514]
Molecular Weight

433.59

Formula

C21H27N3O3S2
CAS No.
SMILES

O=C(O)[C@@H](NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O)CCSC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FTI 276 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FTI 276170006-72-1FTI276FTI-276Farnesyl TransferaseFtaseInhibitorinhibitorinhibit

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