KRAS-IN-47
KRAS-IN-47 is a KRAS inhibitor with IC50 < 50 nM against KRAS G12V. KRAS-IN-47 can be used for the study of cancers.
For research use only. We do not sell to patients.
- CAS No.: 3079342-05-2
- Formula: C33H27D2F5N6O2
- Molecular Weight:638.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
KRAS-IN-47 (Example 28) is a KRAS inhibitor with IC50 < 50 nM against KRAS G12V[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Parmacokinetics
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 3079342-05-2
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Molecular Weight 638.63
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Formula C33H27D2F5N6O2
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SMILES
FC1=C(C2=CC(N)=CC3=C2C(C#C)=C(F)C(F)=C3)N=CC4=C1N=C(N=C4N5[C@@]6([H])[C@](COCC5)([H])[C@@H]6F)OC([2H])([2H])[C@@]78N(CCC8)C[C@@H](C7)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS-IN-47 Related Classifications
HY-179253 Related Classifications
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