2,4,7-Trichloro-8-fluoropyrido[4,3-d]pyrimidine

Cat. No.: HY-W095670 Purity: 99.90%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

2,4,7-Trichloro-8-fluoropyridopyrimidine is a pyridopyrimidine synthetic intermediate of MRTX1133 (HY-134813), which can be used for the synthesis of non-covalent KRAS^G12D inhibitors.

For research use only. We do not sell to patients.

2,4,7-Trichloro-8-fluoropyrido[4,3-d]pyrimidine Chemical Structure

CAS No. : 2454396-80-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
> 100 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

2,4,7-Trichloro-8-fluoropyridopyrimidine is a pyridopyrimidine synthetic intermediate of MRTX1133 (HY-134813), which can be used for the synthesis of non-covalent KRAS^G12D inhibitors^[1].

In Vitro

2,4,7-trichloro-8-fluoropyrido[4,3-d]pyrimidine forms upon heating 2,4,7-Trichloro-8-fluoropyridopyrimidine with POCl₃ and N-ethyl-N-isopropylpropan-2-amine at 100 °C for 1 h ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

252.46

Formula

C₇HCl₃FN₃

CAS No.

2454396-80-4

Appearance

Solid

Color

White to yellow

SMILES

FC1=C(Cl)N=CC2=C(Cl)N=C(Cl)N=C21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (198.05 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9610 mL	19.8051 mL	39.6102 mL
5 mM	0.7922 mL	3.9610 mL	7.9220 mL
10 mM	0.3961 mL	1.9805 mL	3.9610 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (272 KB) SDS (480 KB)

COA (250 KB) HNMR (127 KB) Others (272 KB)

Handling Instructions (2659 KB)

References

[1]. Wang X, et al. Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS^G12D Inhibitor. J Med Chem. 2022;65(4):3123-3133. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9610 mL	19.8051 mL	39.6102 mL	99.0256 mL
	5 mM	0.7922 mL	3.9610 mL	7.9220 mL	19.8051 mL
	10 mM	0.3961 mL	1.9805 mL	3.9610 mL	9.9026 mL
	15 mM	0.2641 mL	1.3203 mL	2.6407 mL	6.6017 mL
	20 mM	0.1981 mL	0.9903 mL	1.9805 mL	4.9513 mL
	25 mM	0.1584 mL	0.7922 mL	1.5844 mL	3.9610 mL
	30 mM	0.1320 mL	0.6602 mL	1.3203 mL	3.3009 mL
	40 mM	0.0990 mL	0.4951 mL	0.9903 mL	2.4756 mL
	50 mM	0.0792 mL	0.3961 mL	0.7922 mL	1.9805 mL
	60 mM	0.0660 mL	0.3301 mL	0.6602 mL	1.6504 mL
	80 mM	0.0495 mL	0.2476 mL	0.4951 mL	1.2378 mL
	100 mM	0.0396 mL	0.1981 mL	0.3961 mL	0.9903 mL