2,4,7-Trichloro-8-fluoropyrido[4,3-d]pyrimidine
Based on 1 Customer Validation
2,4,7-Trichloro-8-fluoropyridopyrimidine is a pyridopyrimidine synthetic intermediate of MRTX1133 (HY-134813), which can be used for the synthesis of non-covalent KRASG12D inhibitors.
For research use only. We do not sell to patients.
- Purity : 99.90%
- CAS No.: 2454396-80-4
- Formula: C7HCl3FN3
- Molecular Weight:252.46
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
![2,4,7-Trichloro-8-fluoropyrido[4,3-d]pyrimidine Chemical Structure](https://file.medchemexpress.com/product_pic/hy-w095670.gif "Click to View 2,4,7-Trichloro-8-fluoropyrido[4,3-d]pyrimidine Chemical Structure")
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
2,4,7-trichloro-8-fluoropyrido[4,3-d]pyrimidine forms upon heating 2,4,7-Trichloro-8-fluoropyridopyrimidine with POCl3 and N-ethyl-N-isopropylpropan-2-amine at 100 °C for 1 h [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2454396-80-4
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Appearance Solid
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Molecular Weight 252.46
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Formula C7HCl3FN3
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Color White to yellow
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SMILES
FC1=C(Cl)N=CC2=C(Cl)N=C(Cl)N=C21
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (198.05 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9610 mL | 19.8051 mL | 39.6102 mL | 99.0256 mL |
| 5 mM | 0.7922 mL | 3.9610 mL | 7.9220 mL | 19.8051 mL | |
| 10 mM | 0.3961 mL | 1.9805 mL | 3.9610 mL | 9.9026 mL | |
| 15 mM | 0.2641 mL | 1.3203 mL | 2.6407 mL | 6.6017 mL | |
| 20 mM | 0.1981 mL | 0.9903 mL | 1.9805 mL | 4.9513 mL | |
| 25 mM | 0.1584 mL | 0.7922 mL | 1.5844 mL | 3.9610 mL | |
| 30 mM | 0.1320 mL | 0.6602 mL | 1.3203 mL | 3.3009 mL | |
| 40 mM | 0.0990 mL | 0.4951 mL | 0.9903 mL | 2.4756 mL | |
| 50 mM | 0.0792 mL | 0.3961 mL | 0.7922 mL | 1.9805 mL | |
| 60 mM | 0.0660 mL | 0.3301 mL | 0.6602 mL | 1.6504 mL | |
| 80 mM | 0.0495 mL | 0.2476 mL | 0.4951 mL | 1.2378 mL | |
| 100 mM | 0.0396 mL | 0.1981 mL | 0.3961 mL | 0.9903 mL |
2,4,7-Trichloro-8-fluoropyrido[4,3-d]pyrimidine Related Classifications
HY-W095670 Related Classifications
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