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Cat. No.: HY-126180

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BAY-866

BAY-866, a sulfamide campound, is an allosteric MEK1 inhibitor with an IC₅₀ of 14 nM. BAY-866 inhibits cell growth of A375 (BRAF) and HCT116 (K-Ras) with IC₅₀s of 13 nM and 277 nM, respectively. BAY-866 inhibits tumor growth in K-Ras-mutated A549 xenograft model.

For research use only. We do not sell to patients.

CAS No.: 1836185-18-2
Formula: C₁₉H₁₃F₄IN₄O₄S
Molecular Weight:596.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BAY-866 Chemical Structure

CAS No.: 1836185-18-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All MEK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	13 nM Compound: 27; BAY-866	Antiproliferative activity against human A375 cells harboring BRAF(V600E) mutation after 72 hrs by cell titer glow cell titer glow FCTGI assay Antiproliferative activity against human A375 cells harboring BRAF(V600E) mutation after 72 hrs by cell titer glow cell titer glow FCTGI assay	[PMID: 26611920]
A549	IC₅₀	314 nM Compound: 27; BAY-866	Antiproliferative activity against human A549 cells harboring K-Ras mutation Antiproliferative activity against human A549 cells harboring K-Ras mutation	[PMID: 26611920]
COLO 205	IC₅₀	42 nM Compound: 27; BAY-866	Antiproliferative activity against human COLO205 cells harboring BRAF mutation Antiproliferative activity against human COLO205 cells harboring BRAF mutation	[PMID: 26611920]
HCT-116	IC₅₀	277 nM Compound: 27; BAY-866	Antiproliferative activity against human HCT116 cells harboring K-Ras G13D mutation Antiproliferative activity against human HCT116 cells harboring K-Ras G13D mutation	[PMID: 26611920]
HepG2	IC₅₀	2 nM Compound: 27; BAY-866	Antiproliferative activity against human HepG2 cells harboring N-Ras mutation Antiproliferative activity against human HepG2 cells harboring N-Ras mutation	[PMID: 26611920]
MCF7	IC₅₀	>10000 nM Compound: 27; BAY-866	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 26611920]

Chemical Information

CAS No. 1836185-18-2
Molecular Weight 596.29
Formula C₁₉H₁₃F₄IN₄O₄S
SMILES

O=C(C1=C(C=C(C(F)=C1NC2=CC=C(C=C2F)I)F)OC3=CC=C(C(NS(=O)(N)=O)=C3)F)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hartung IV, et al. Optimization of allosteric MEK inhibitors. Part 2: Taming the sulfamide group balances compound distribution properties. Bioorg Med Chem Lett. 2016 Jan 1;26(1):186-93. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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