2. MAPK/ERK Pathway
  3. MEK
  4. BAY-866

BAY-866, a sulfamide campound, is an allosteric MEK1 inhibitor with an IC50 of 14 nM. BAY-866 inhibits cell growth of A375 (BRAF) and HCT116 (K-Ras) with IC50s of 13 nM and 277 nM, respectively. BAY-866 inhibits tumor growth in K-Ras-mutated A549 xenograft model.

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BAY-866

BAY-866 Chemical Structure

CAS No. : 1836185-18-2

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BAY-866 Related Antibodies

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Description

BAY-866, a sulfamide campound, is an allosteric MEK1 inhibitor with an IC50 of 14 nM. BAY-866 inhibits cell growth of A375 (BRAF) and HCT116 (K-Ras) with IC50s of 13 nM and 277 nM, respectively. BAY-866 inhibits tumor growth in K-Ras-mutated A549 xenograft model[1].

Cellular Effect
Cell Line Type Value Description References
A-375 IC50
13 nM
Compound: 27; BAY-866
Antiproliferative activity against human A375 cells harboring BRAF(V600E) mutation after 72 hrs by cell titer glow cell titer glow FCTGI assay
Antiproliferative activity against human A375 cells harboring BRAF(V600E) mutation after 72 hrs by cell titer glow cell titer glow FCTGI assay
[PMID: 26611920]
A549 IC50
314 nM
Compound: 27; BAY-866
Antiproliferative activity against human A549 cells harboring K-Ras mutation
Antiproliferative activity against human A549 cells harboring K-Ras mutation
[PMID: 26611920]
COLO 205 IC50
42 nM
Compound: 27; BAY-866
Antiproliferative activity against human COLO205 cells harboring BRAF mutation
Antiproliferative activity against human COLO205 cells harboring BRAF mutation
[PMID: 26611920]
HCT-116 IC50
277 nM
Compound: 27; BAY-866
Antiproliferative activity against human HCT116 cells harboring K-Ras G13D mutation
Antiproliferative activity against human HCT116 cells harboring K-Ras G13D mutation
[PMID: 26611920]
HepG2 IC50
2 nM
Compound: 27; BAY-866
Antiproliferative activity against human HepG2 cells harboring N-Ras mutation
Antiproliferative activity against human HepG2 cells harboring N-Ras mutation
[PMID: 26611920]
MCF7 IC50
> 10000 nM
Compound: 27; BAY-866
Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
[PMID: 26611920]
Molecular Weight

596.29

Formula

C19H13F4IN4O4S
CAS No.
SMILES

O=C(C1=C(C=C(C(F)=C1NC2=CC=C(C=C2F)I)F)OC3=CC=C(C(NS(=O)(N)=O)=C3)F)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BAY-866 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-8661836185-18-2BAY866BAY 866MEKMitogen-activated protein kinase kinaseMAPKKMAP2KInhibitorinhibitorinhibit

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