1836185-18-2
1836185-18-2
Chemical Structure
BAY-866
- CAS No.: 1836185-18-2
- Formula:C19H13F4IN4O4S
- Molecular Weight:596.29
IUPAC Name: 3,4-difluoro-6-(4-fluoro-3-(sulfamoylamino)phenoxy)-2-((2-fluoro-4-iodophenyl)amino)benzamide
InChIKey: LTQRQYGKFXIKSB-UHFFFAOYSA-N
SMILES: O=C(C1=C(C=C(C(F)=C1NC2=CC=C(C=C2F)I)F)OC3=CC=C(C(NS(=O)(N)=O)=C3)F)N
Biological Activity: BAY-866, a sulfamide campound, is an allosteric MEK1 inhibitor with an IC50 of 14 nM. BAY-866 inhibits cell growth of A375 (BRAF) and HCT116 (K-Ras) with IC50s of 13 nM and 277 nM, respectively. BAY-866 inhibits tumor growth in K-Ras-mutated A549 xenograft model[1].
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BAY-866 | BAY-866, a sulfamide campound, is an allosteric MEK1 inhibitor with an IC50 of 14 nM. BAY-866 inhibits cell growth of A375 (BRAF) and HCT116 (K-Ras) with IC50s of 13 nM and 277 nM, respectively. BAY-866 inhibits tumor growth in K-Ras-mutated A549 xenograft model. | |||||||||||||||||||||
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References
Keywords
