Neoantimycin

Cat. No.: HY-121459: Data Sheet Handling Instructions
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Neoantimycin is a GRP78/BiP and K-Ras regulator with anticancer activity. Its biosynthesis is catalyzed by a hybrid nonribosomal peptide synthetase/polyketide synthase (NRPS/PKS) system.

For research use only. We do not sell to patients.

Neoantimycin Chemical Structure

CAS No. : 22862-63-1

Size	Price	Stock	Quantity
500 μg		Get quote 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31

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K-Ras H-Ras N-Ras Ras

Biological Activity
Purity & Documentation
References
Customer Review

Description

Neoantimycin is a GRP78/BiP and K-Ras regulator with anticancer activity. Its biosynthesis is catalyzed by a hybrid nonribosomal peptide synthetase/polyketide synthase (NRPS/PKS) system^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.04 nM Compound: 10	Cytotoxicity against human A549 cells expressing K-Ras G12C mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human A549 cells expressing K-Ras G12C mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 38662398]
DLD-1	IC₅₀	59 nM Compound: 10	Cytotoxicity against human DLD-1 cells expressing K-Ras G13D mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human DLD-1 cells expressing K-Ras G13D mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 38662398]
HT-29	IC₅₀	0.6 nM Compound: 10	Cytotoxicity against wild type human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against wild type human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 38662398]
NCI-H1299	IC₅₀	10.5 nM Compound: 10	Cytotoxicity against human NCI-H1299 cells expressing N-ras mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human NCI-H1299 cells expressing N-ras mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 38662398]
NCI-H460	IC₅₀	316.4 nM Compound: 10	Cytotoxicity against human NCI-H460 cells expressing K-Ras Q61H mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human NCI-H460 cells expressing K-Ras Q61H mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 38662398]
NCM460	IC₅₀	0.24 nM Compound: 10	Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 38662398]
SW-620	IC₅₀	3.8 nM Compound: 10	Cytotoxicity against human SW620 cells expressing K-Ras G12V mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human SW620 cells expressing K-Ras G12V mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 38662398]

Molecular Weight

698.76

Formula

C₃₆H₄₆N₂O₁₂

CAS No.

22862-63-1

SMILES

O=C(C1=C(C(NC=O)=CC=C1)O)N[C@@H]2C(O[C@H](C(O[C@@H]([C@@H](C(C)(C(O[C@@](C(O[C@@H]2C)=O)([H])[C@@H](C)CC)=O)C)O)CC3=CC=CC=C3)=O)C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Skyrud W, et al. Biosynthesis of the 15-Membered Ring Depsipeptide Neoantimycin. ACS Chem Biol. 2018 May 18;13(5):1398-1406. [Content Brief]

Neoantimycin Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neoantimycin22862-63-1HSPRasHeat shock proteinsInhibitorinhibitorinhibit

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