Neoantimycin
Neoantimycin is a GRP78/BiP and K-Ras regulator with anticancer activity. Its biosynthesis is catalyzed by a hybrid nonribosomal peptide synthetase/polyketide synthase (NRPS/PKS) system.
For research use only. We do not sell to patients.
- CAS No.: 22862-63-1
- Formula: C36H46N2O12
- Molecular Weight:698.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.04 nM
Compound: 10
|
Cytotoxicity against human A549 cells expressing K-Ras G12C mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human A549 cells expressing K-Ras G12C mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
|
[PMID: 38662398] |
| DLD-1 | IC50 |
59 nM
Compound: 10
|
Cytotoxicity against human DLD-1 cells expressing K-Ras G13D mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human DLD-1 cells expressing K-Ras G13D mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
|
[PMID: 38662398] |
| HT-29 | IC50 |
0.6 nM
Compound: 10
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Cytotoxicity against wild type human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against wild type human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
|
[PMID: 38662398] |
| NCI-H1299 | IC50 |
10.5 nM
Compound: 10
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Cytotoxicity against human NCI-H1299 cells expressing N-ras mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human NCI-H1299 cells expressing N-ras mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
|
[PMID: 38662398] |
| NCI-H460 | IC50 |
316.4 nM
Compound: 10
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Cytotoxicity against human NCI-H460 cells expressing K-Ras Q61H mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human NCI-H460 cells expressing K-Ras Q61H mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 38662398] |
| NCM460 | IC50 |
0.24 nM
Compound: 10
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Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
|
[PMID: 38662398] |
| SW-620 | IC50 |
3.8 nM
Compound: 10
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Cytotoxicity against human SW620 cells expressing K-Ras G12V mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human SW620 cells expressing K-Ras G12V mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
|
[PMID: 38662398] |
Chemical Information
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CAS No. 22862-63-1
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Molecular Weight 698.76
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Formula C36H46N2O12
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SMILES
O=C(C1=C(C(NC=O)=CC=C1)O)N[C@@H]2C(O[C@H](C(O[C@@H]([C@@H](C(C)(C(O[C@@](C(O[C@@H]2C)=O)([H])[C@@H](C)CC)=O)C)O)CC3=CC=CC=C3)=O)C(C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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