2. PROTAC
  3. Target Protein Ligand-Linker Conjugates
  4. K-Ras ligand-Linker Conjugate 5

K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.

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K-Ras ligand-Linker Conjugate 5

K-Ras ligand-Linker Conjugate 5 Estructura química

No. CAS : 2378261-85-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
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K-Ras ligand-Linker Conjugate 5 Related Antibodies

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Descripciòn

K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

K-Ras ligand-Linker Conjugate 5 Related Antibodies
Peso molecular

789.96

Fòrmula

C42H59N7O8
No. CAS
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCO)C6)=N2)CC1)OC(C)(C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvente y solubilidad
In Vitro: 

DMSO : ≥ 100 mg/mL (126.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2659 mL 6.3294 mL 12.6589 mL
5 mM 0.2532 mL 1.2659 mL 2.5318 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2659 mL 6.3294 mL 12.6589 mL 31.6472 mL
5 mM 0.2532 mL 1.2659 mL 2.5318 mL 6.3294 mL
10 mM 0.1266 mL 0.6329 mL 1.2659 mL 3.1647 mL
15 mM 0.0844 mL 0.4220 mL 0.8439 mL 2.1098 mL
20 mM 0.0633 mL 0.3165 mL 0.6329 mL 1.5824 mL
25 mM 0.0506 mL 0.2532 mL 0.5064 mL 1.2659 mL
30 mM 0.0422 mL 0.2110 mL 0.4220 mL 1.0549 mL
40 mM 0.0316 mL 0.1582 mL 0.3165 mL 0.7912 mL
50 mM 0.0253 mL 0.1266 mL 0.2532 mL 0.6329 mL
60 mM 0.0211 mL 0.1055 mL 0.2110 mL 0.5275 mL
80 mM 0.0158 mL 0.0791 mL 0.1582 mL 0.3956 mL
100 mM 0.0127 mL 0.0633 mL 0.1266 mL 0.3165 mL
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K-Ras ligand-Linker Conjugate 5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K-Ras ligand-Linker Conjugate 52378261-85-7Target Protein Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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Nombre del producto:
K-Ras ligand-Linker Conjugate 5
Cat. No.:
HY-130823
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