K-Ras ligand-Linker Conjugate 5

Name: K-Ras ligand-Linker Conjugate 5
Brand: MedChemExpress
SKU: HY-130823
Rating: 4.5 (0 reviews)

製品番号: HY-130823 純度: 99.79%: Data Sheet SDS COA 取扱説明書
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K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

K-Ras ligand-Linker Conjugate 5 構造式

CAS 番号 : 2378261-85-7

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 191	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 191	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$110	在庫あり	Estimated Time of Arrival: December 31
10 mg	$175	在庫あり	Estimated Time of Arrival: December 31
25 mg	$350	在庫あり	Estimated Time of Arrival: December 31
50 mg	$565	在庫あり	Estimated Time of Arrival: December 31
100 mg	$900	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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Based on 0 publication(s) in Google Scholar

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製品説明

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

789.96

分子式

C₄₂H₅₉N₇O₈

CAS 番号

2378261-85-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCO)C6)=N2)CC1)OC(C)(C)C

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (126.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2659 mL	6.3294 mL	12.6589 mL
5 mM	0.2532 mL	1.2659 mL	2.5318 mL
10 mM	0.1266 mL	0.6329 mL	1.2659 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.79%

Select Batch:

データシート (270 KB) SDS (393 KB)

COA (250 KB) HNMR (235 KB) LCMS (96 KB)

取扱説明書 (2659 KB)

参考文献

[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2659 mL	6.3294 mL	12.6589 mL	31.6472 mL
	5 mM	0.2532 mL	1.2659 mL	2.5318 mL	6.3294 mL
	10 mM	0.1266 mL	0.6329 mL	1.2659 mL	3.1647 mL
	15 mM	0.0844 mL	0.4220 mL	0.8439 mL	2.1098 mL
	20 mM	0.0633 mL	0.3165 mL	0.6329 mL	1.5824 mL
	25 mM	0.0506 mL	0.2532 mL	0.5064 mL	1.2659 mL
	30 mM	0.0422 mL	0.2110 mL	0.4220 mL	1.0549 mL
	40 mM	0.0316 mL	0.1582 mL	0.3165 mL	0.7912 mL
	50 mM	0.0253 mL	0.1266 mL	0.2532 mL	0.6329 mL
	60 mM	0.0211 mL	0.1055 mL	0.2110 mL	0.5275 mL
	80 mM	0.0158 mL	0.0791 mL	0.1582 mL	0.3956 mL
	100 mM	0.0127 mL	0.0633 mL	0.1266 mL	0.3165 mL