K-Ras ligand-Linker Conjugate 5
Based on 1 Customer Validation
K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 2378261-85-7
- Formula: C42H59N7O8
- Molecular Weight:789.96
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2378261-85-7
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Appearance Solid
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Molecular Weight 789.96
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Formula C42H59N7O8
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Color Light yellow to yellow
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SMILES
O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCO)C6)=N2)CC1)OC(C)(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (126.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2659 mL | 6.3294 mL | 12.6589 mL | 31.6472 mL |
| 5 mM | 0.2532 mL | 1.2659 mL | 2.5318 mL | 6.3294 mL | |
| 10 mM | 0.1266 mL | 0.6329 mL | 1.2659 mL | 3.1647 mL | |
| 15 mM | 0.0844 mL | 0.4220 mL | 0.8439 mL | 2.1098 mL | |
| 20 mM | 0.0633 mL | 0.3165 mL | 0.6329 mL | 1.5824 mL | |
| 25 mM | 0.0506 mL | 0.2532 mL | 0.5064 mL | 1.2659 mL | |
| 30 mM | 0.0422 mL | 0.2110 mL | 0.4220 mL | 1.0549 mL | |
| 40 mM | 0.0316 mL | 0.1582 mL | 0.3165 mL | 0.7912 mL | |
| 50 mM | 0.0253 mL | 0.1266 mL | 0.2532 mL | 0.6329 mL | |
| 60 mM | 0.0211 mL | 0.1055 mL | 0.2110 mL | 0.5275 mL | |
| 80 mM | 0.0158 mL | 0.0791 mL | 0.1582 mL | 0.3956 mL | |
| 100 mM | 0.0127 mL | 0.0633 mL | 0.1266 mL | 0.3165 mL |
K-Ras ligand-Linker Conjugate 5 Related Classifications
HY-130823 Related Classifications
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