KRAS-IN-59
Based on 1 Customer Validation
K-Ras-IN-58 is a K-RAS inhibitor and shows inhibitory activity against KRASG12D, KRASG12C and KRAS WT. K-Ras-IN-58 inhibits proliferation of cancer cells.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 3034588-80-9
- Formula: C38H39F3N8O3
- Molecular Weight:712.76
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KRas G12D ≤100 nM (IC50) |
K-Ras WT ≤100 nM (IC50) |
KRas G12C 0.1-1 μM (IC50) |
KRas G12V >10 μM (IC50) |
K-Ras-IN-58 (Compound 1) (2 h) inhibits KRASG12D, KRASG12C, KRASG12V, and KRAS wild-type proteins, with the highest potency against KRASG12D and KRAS wild-type (IC50 ≤100 nM), followed by KRASG12C, and lowest potency against KRASG12V[1].
K-Ras-IN-58 inhibits proliferation of AGS, H358, SW480, and A375 cell lines, with the highest potency against AGS cells (IC50 ≤100 nM), followed by H358 cells, and equivalent lower potency against SW480 and A375 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3034588-80-9
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Appearance Solid
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Molecular Weight 712.76
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Formula C38H39F3N8O3
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Color Off-white to light yellow
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SMILES
FC1=C(C2=CC(O)=CC3=C2C(CC)=C(F)C=C3)N=CC4=C1N=C(N=C4N5CC6=C7C(C(N(CC7)C)=O)=NN6CCC5)OC[C@@]89N(CCC9)C[C@@H](C8)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (140.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4030 mL | 7.0150 mL | 14.0300 mL | 35.0749 mL |
| 5 mM | 0.2806 mL | 1.4030 mL | 2.8060 mL | 7.0150 mL | |
| 10 mM | 0.1403 mL | 0.7015 mL | 1.4030 mL | 3.5075 mL | |
| 15 mM | 0.0935 mL | 0.4677 mL | 0.9353 mL | 2.3383 mL | |
| 20 mM | 0.0701 mL | 0.3507 mL | 0.7015 mL | 1.7537 mL | |
| 25 mM | 0.0561 mL | 0.2806 mL | 0.5612 mL | 1.4030 mL | |
| 30 mM | 0.0468 mL | 0.2338 mL | 0.4677 mL | 1.1692 mL | |
| 40 mM | 0.0351 mL | 0.1754 mL | 0.3507 mL | 0.8769 mL | |
| 50 mM | 0.0281 mL | 0.1403 mL | 0.2806 mL | 0.7015 mL | |
| 60 mM | 0.0234 mL | 0.1169 mL | 0.2338 mL | 0.5846 mL | |
| 80 mM | 0.0175 mL | 0.0877 mL | 0.1754 mL | 0.4384 mL | |
| 100 mM | 0.0140 mL | 0.0701 mL | 0.1403 mL | 0.3507 mL |
KRAS-IN-59 Related Classifications
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