1. Metabolic Enzyme/Protease
    Apoptosis
  2. Farnesyl Transferase
    Apoptosis
  3. LB42708

LB42708 

Cat. No.: HY-15879
Handling Instructions

LB42708 is a potent, selective and orally active farnesyltransferase inhibitor. LB42708 inhibits farnesylation of H-Ras, N-Ras and K-Ras4B with IC50s of 0.8 nM, 1.2 nM and 2.0 nM, respectively.

For research use only. We do not sell to patients.

LB42708 Chemical Structure

LB42708 Chemical Structure

CAS No. : 226929-39-1

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Description

LB42708 is a potent, selective and orally active farnesyltransferase inhibitor. LB42708 inhibits farnesylation of H-Ras, N-Ras and K-Ras4B with IC50s of 0.8 nM, 1.2 nM and 2.0 nM, respectively[1].

In Vitro

LB42708 induces cell death despite K-ras prenylation. Growth inhibition by LB42708 is accompanied by G1 and G2/M cell cycle arrests in H-ras and K-ras-transformed RIE cells, respectively. LB42708 induces the upregulation of p21(CIP1/WAF1) and RhoB above the basal level that leads to the cell cycle arrest and to distinct morphological alterations of ras-transformed rat intestinal epithelial (RIE) cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

555.47

Formula

C30H27BrN4O2

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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LB42708
Cat. No.:
HY-15879
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