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Isoforms Recommended:	N-Ras

Results for "

N-Ras

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ras (4) 5-HT Receptor (1) Adrenergic Receptor (1) Apoptosis (2) Autophagy (1) Dopamine Receptor (1) Farnesyl Transferase (3) ICMT (2) MAGL (1) MEK (1) Molecular Glues (1) Phospholipase (1) Raf (4) Small Interfering RNA (siRNA) (3) Src (1)
By Research Areas:	Cancer (14) Endocrinology (1) Infection (2) Inflammation/Immunology (1) Neurological Disease (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: Ras

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-142161

ABD957 1 Publications Verification	MAGL	Cancer
ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC₅₀ of 0.21 µM for ABHD17B. ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells .

HY-15879

LB42708	Farnesyl Transferase Apoptosis	Inflammation/Immunology
LB42708 is a potent, selective and orally active farnesyltransferase inhibitor. LB42708 inhibits farnesylation of H-Ras, *N-Ras* and K-Ras4B with IC₅₀s of 0.8 nM, 1.2 nM and 2.0 nM, respectively .

HY-RS09558

NRAS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NRAS Human Pre-designed siRNA Set A contains three designed siRNAs for NRAS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NRAS Human Pre-designed siRNA Set A NRAS Human Pre-designed siRNA Set A

HY-RS09559

Nras Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nras Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nras gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nras Mouse Pre-designed siRNA Set A Nras Mouse Pre-designed siRNA Set A

HY-RS09560

Nras Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nras Rat Pre-designed siRNA Set A contains three designed siRNAs for Nras gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nras Rat Pre-designed siRNA Set A Nras Rat Pre-designed siRNA Set A

HY-15136

Lonafarnib Maximum Cited Publications 7 Publications Verification Sch66336	Farnesyl Transferase Ras Autophagy	Infection Cancer
Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and *N-ras* with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.

HY-156500

ICMT-IN-1	ICMT	Cancer
ICMT-IN-1 (compound 75) is an inhibitor of ICMT (IC₅₀=0.0013 μM). ICMT-IN-1 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras .

HY-149705

ICMT-IN-7	ICMT	Cancer
ICMT-IN-7 (compound 74) is an inhibitor of ICMT (IC₅₀=0.015 μM). ICMT-IN-7 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras .

HY-15136B

(Rac)-Lonafarnib Sch66336 racemate	Farnesyl Transferase	Infection Cancer
(Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and *N-ras* with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities .

HY-101641

NRA-0160	Dopamine Receptor 5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
NRA-0160 is a selective dopamine D4 receptor antagonist, with a K_i value of 0.48 nM and with negligible affinity for dopamine D2 receptor (K_i: >10000 nM), D3 receptor (K_i: 39 nM), rat 5-HT2A receptor (K_i: 180 nM) and rat α1 adrenoceptor (K_i: 237 nM).

HY-122866

ZT-12-037-01	Ras	Cancer
ZT-12-037-01 is a STK19-targeted inhibitor, has a high-affinity interaction with STK19 protein and inhibits oncogenic NRAS-driven melanocyte malignant transformation. ZT-12-037-01 is an ATP-competitive inhibitor, inhibiting phosphorylation of NRAS (major isoform of Ras family) with an IC₅₀ of 24 nM .

HY-107415

PLX7922

Raf Cancer

PLX7922, a RAF inhibitor, can bind with BRAF ^V600E. PLX7922 inhibits pERK in BRAF ^V600E cell lines, and activates pERK in mutant NRAS cell lines .

PLX7922	Raf	Cancer
PLX7922, a RAF inhibitor, can bind with BRAF ^V600E. PLX7922 inhibits pERK in BRAF ^V600E cell lines, and activates pERK in mutant NRAS cell lines .

HY-108887

Anticancer agent 124	Raf	Cancer
Anticancer agent 124 is an orally active, highly selective and potent pan RAF inhibitor. Anticancer agent 124 inhibits MAPK signalling in BRAF V600E, NRAS and KRAS mutant tumor cells .

HY-156228

RGB-1	Others	Cancer
RGB-1 is a polycyclic aromatic hydrocarbon molecule and a stabilizer of RNA G-quadruplexes. RGB-1 can promote the inhibition of RNA translation and reduce the expression of NRAS proto-oncogene in breast cancer cells .

HY-120911

Palmostatin B	Phospholipase	Cancer
Palmostatin B is an Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitor. Palmostatin B reduces cell viability in a panel of NRAS mutant melanoma cell lines. Palmostatin B inhibits Ras depalmitoylation in cells .

HY-12847

CCT241161	Raf Src Apoptosis	Cancer
CCT241161 is an orally active pan-RAF inhibitor with IC₅₀s of 3, 6, 10, 15 and 30 nM for LCK, CRAF, SRC, V600E-BRAF and BRAF, respectively. CCT241161 shows good activity to in BRAF and *NRAS* mutant melanomas. CCT241161 also exhibits anticancer cell proliferative activity .

HY-156498

RMC-7977	Ras	Cancer
RMC-7977 is a reversible, tri-complex RAS inhibitor with broad spectrum activity for both mutant and wild-type (WT) KRAS, NRAS, and HRAS variants.RMC-7977 can lead to tumor regressions and was well tolerated in diverse RAS-addicted preclinical cancer models. RMC-7977 also can inhibit the growth of KRAS ^G12C cancer models .

HY-158115

NST-628	Molecular Glues Raf MEK	Cancer
NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation. NST-628 also binds RAF and prevents the formation of BRAF-CRAF and BRAF-ARAF heterodimers, effectively inhibiting the RAS-MAPK pathway. NST-628 inhibits RAS- and RAF-driven cancers and demonstrated potent inhibition in mutant KRAS, NRAS, BRAF class II/III, and NF1-mutant tumors .

HY-122862

RAS inhibitor Abd-7 1 Publications Verification	Ras	Cancer
RAS inhibitor Abd-7, a potent RAS-binding compound (K_d=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P73741

	NRAS Protein, Human (His, solution) GTPase NRas; Transforming protein N-Ras; NRas; HRas1	Human	E. coli
	NRAS protein is a member of the Ras family that binds GDP/GTP and has intrinsic GTPase activity. This property enables NRAS to actively regulate cellular processes by cycling between a GDP-bound inactive state and a GTP-bound active state. NRAS Protein, Human (His, solution) is the recombinant human-derived NRAS protein, expressed by E. coli , with N-His labeled tag. The total length of NRAS Protein, Human (His, solution) is 186 a.a., with molecular weight of ~24 kDa.

HY-P73741A

	NRAS Protein, Human (N-His) GTPase NRas; Transforming protein N-Ras; NRas; HRas1	Human	E. coli
	NRAS protein is a member of the Ras family that binds GDP/GTP and has intrinsic GTPase activity. This property enables NRAS to actively regulate cellular processes by cycling between a GDP-bound inactive state and a GTP-bound active state. NRAS Protein, Human (N-His) is the recombinant human-derived NRAS protein, expressed by E. coli , with N-His labeled tag. The total length of NRAS Protein, Human (N-His) is 186 a.a., with molecular weight of ~23 kDa.


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